Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1082655..1083262 Replicon chromosome
Accession NZ_CP119223
Organism Acinetobacter proteolyticus strain AP54

Toxin (Protein)


Gene name vapC Uniprot ID A0A1E7QXN7
Locus tag PY247_RS05085 Protein ID WP_070076683.1
Coordinates 1082655..1083074 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PY247_RS05090 Protein ID WP_275574143.1
Coordinates 1083074..1083262 (-) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY247_RS05050 (PY247_05050) 1078295..1078998 - 704 Protein_975 DUF1003 domain-containing protein -
PY247_RS05055 (PY247_05055) 1079118..1079357 - 240 WP_159413965.1 hypothetical protein -
PY247_RS05060 (PY247_05060) 1079492..1080193 - 702 WP_275573734.1 hypothetical protein -
PY247_RS05065 (PY247_05065) 1080318..1081016 - 699 WP_275573735.1 hypothetical protein -
PY247_RS05070 (PY247_05070) 1081081..1081599 - 519 WP_275573736.1 GNAT family N-acetyltransferase -
PY247_RS05075 (PY247_05075) 1081678..1082253 - 576 WP_070076682.1 DUF4126 domain-containing protein -
PY247_RS05080 (PY247_05080) 1082381..1082524 - 144 WP_004637424.1 zinc ribbon-containing protein -
PY247_RS05085 (PY247_05085) 1082655..1083074 - 420 WP_070076683.1 type II toxin-antitoxin system VapC family toxin Toxin
PY247_RS05090 (PY247_05090) 1083074..1083262 - 189 WP_275574143.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PY247_RS05095 (PY247_05095) 1083534..1086153 - 2620 Protein_984 Fe/S-dependent 2-methylisocitrate dehydratase AcnD -
PY247_RS05100 (PY247_05100) 1086153..1087309 - 1157 Protein_985 2-methylcitrate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-128)

Antitoxin

SpoVT-AbrB domain

(1-29)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15888.03 Da        Isoelectric Point: 6.3296

>T273920 WP_070076683.1 NZ_CP119223:c1083074-1082655 [Acinetobacter proteolyticus]
MQTQYLLDTNICIYISKHQPENVRQHFEKHLPNRNILISVVTLGELRFGAEKSQSKGKALKVIDEFTSMIQVAELDEDVA
DHYAQIRQALSSQGQIIGSNDLWLAAHARANNWVMVTNNEKEFLRVDGLRVENWVSTPL

Download         Length: 420 bp

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 7614.53 Da        Isoelectric Point: 4.2298

>AT273920 WP_275574143.1 NZ_CP119223:c1083262-1083074 [Acinetobacter proteolyticus]
IRLPKEFRFESTEVEIFRRGDEVILREKPITAERLFNVLAQMPDDFYEEERVDQPPQEREEF

Download         Length: 189 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7QXN7

Antitoxin

Source ID Structure

References