Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3121435..3121970 Replicon chromosome
Accession NZ_CP119199
Organism Mycolicibacterium vanbaalenii strain L1I3

Toxin (Protein)


Gene name mazF Uniprot ID A1T986
Locus tag PXR06_RS14860 Protein ID WP_011780141.1
Coordinates 3121435..3121767 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PXR06_RS14865 Protein ID WP_041306533.1
Coordinates 3121764..3121970 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXR06_RS14840 3117529..3119001 + 1473 WP_275572501.1 hypothetical protein -
PXR06_RS14845 3119249..3119746 + 498 WP_275572502.1 YaeQ family protein -
PXR06_RS14850 3119819..3120957 + 1139 WP_100522050.1 IS3 family transposase -
PXR06_RS14855 3121071..3121256 - 186 WP_208676593.1 hypothetical protein -
PXR06_RS14860 3121435..3121767 - 333 WP_011780141.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PXR06_RS14865 3121764..3121970 - 207 WP_041306533.1 DUF3018 family protein Antitoxin
PXR06_RS14870 3122290..3122940 - 651 WP_275572503.1 TIGR03086 family metal-binding protein -
PXR06_RS14875 3123004..3123951 + 948 WP_036372912.1 WYL domain-containing protein -
PXR06_RS14880 3124082..3124774 - 693 WP_011780145.1 WYL domain-containing protein -
PXR06_RS14885 3124796..3125200 - 405 WP_036372910.1 nuclear transport factor 2 family protein -
PXR06_RS14890 3125429..3126225 + 797 Protein_2959 LLM class F420-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3108683..3131166 22483


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11972.85 Da        Isoelectric Point: 8.7573

>T273919 WP_011780141.1 NZ_CP119199:c3121767-3121435 [Mycolicibacterium vanbaalenii]
VNRGEIWTVAGGVYAAKPRPAVIVQDDLFDATSSVTVAPMTSTLLDAPLMRIRIAGGDGRLSGLDHDRDVMIDKLTTVRR
SNVHVRVGRLTAEQVVEVERTMMAFLGLAR

Download         Length: 333 bp

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7932.81 Da        Isoelectric Point: 4.8146

>AT273919 WP_041306533.1 NZ_CP119199:c3121970-3121764 [Mycolicibacterium vanbaalenii]
MAVRDRVGEYRRRMRERGLRPLQVWVPDVRTEAFAAEARRQASLVARADESGDDQNFIEAISTPWDEE

Download         Length: 207 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1T986

Antitoxin

Source ID Structure

References