Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1701865..1702445 Replicon chromosome
Accession NZ_CP119199
Organism Mycolicibacterium vanbaalenii strain L1I3

Toxin (Protein)


Gene name doc Uniprot ID A1T5K1
Locus tag PXR06_RS08130 Protein ID WP_011778876.1
Coordinates 1701865..1702251 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2S8LB97
Locus tag PXR06_RS08135 Protein ID WP_036369753.1
Coordinates 1702248..1702445 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXR06_RS08115 1697096..1698511 + 1416 WP_041305954.1 NAD(P)H-quinone dehydrogenase -
PXR06_RS08120 1698691..1700448 + 1758 WP_011778874.1 glycerol-3-phosphate dehydrogenase/oxidase -
PXR06_RS08125 1700445..1701302 + 858 WP_275572190.1 pseudouridine synthase -
PXR06_RS08130 1701865..1702251 - 387 WP_011778876.1 Fic family protein Toxin
PXR06_RS08135 1702248..1702445 - 198 WP_036369753.1 hypothetical protein Antitoxin
PXR06_RS08140 1702727..1703008 + 282 WP_275572541.1 RNA-binding protein -
PXR06_RS08145 1703008..1703778 + 771 WP_275572191.1 SDR family oxidoreductase -
PXR06_RS08150 1703857..1704636 - 780 WP_222880557.1 enoyl-CoA hydratase-related protein -
PXR06_RS08155 1704647..1705315 - 669 WP_011778880.1 TetR family transcriptional regulator -
PXR06_RS08160 1705385..1706425 + 1041 WP_275572192.1 ferredoxin reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13754.44 Da        Isoelectric Point: 4.1262

>T273918 WP_011778876.1 NZ_CP119199:c1702251-1701865 [Mycolicibacterium vanbaalenii]
VTEYLDRDDVLTAGSAAVGQVVHVSDYGLLDAAVARPRATVFGLDAYPDNFTKAAALLQSLARNHALVDGNMPMAWAAAW
IFLHINGISLGEFDVDDAEVFMNNVAINGDLEIDYVANKLNSYAKPAQ

Download         Length: 387 bp

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7074.95 Da        Isoelectric Point: 7.2050

>AT273918 WP_036369753.1 NZ_CP119199:c1702445-1702248 [Mycolicibacterium vanbaalenii]
MPSLNVSFTEEELATVRAAAANDEVSLRTFAHAAILSAASEHRRRVAEAARIVAERSAELNRRLA

Download         Length: 198 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A1T5K1

Antitoxin

Source ID Structure
AlphaFold DB A0A2S8LB97

References