Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FaRel2-ATfaRel2/-
Location 158462..159257 Replicon plasmid p21-D-5b
Accession NZ_CP119189
Organism Clostridium perfringens strain 21-D-5

Toxin (Protein)


Gene name faRel2 Uniprot ID -
Locus tag M2J13_RS15980 Protein ID WP_173706021.1
Coordinates 158462..159052 (+) Length 197 a.a.

Antitoxin (Protein)


Gene name ATfaRel2 Uniprot ID B1BRB4
Locus tag M2J13_RS15985 Protein ID WP_004456691.1
Coordinates 159033..159257 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M2J13_RS15925 153704..153916 + 213 WP_173706015.1 hypothetical protein -
M2J13_RS15930 153903..154862 + 960 WP_173706016.1 hypothetical protein -
M2J13_RS15935 154872..155144 + 273 WP_173706017.1 hypothetical protein -
M2J13_RS15940 155260..155520 + 261 WP_004456627.1 hypothetical protein -
M2J13_RS15945 155813..156166 + 354 WP_173706018.1 hypothetical protein -
M2J13_RS15950 156183..156572 + 390 WP_173706019.1 hypothetical protein -
M2J13_RS15955 156589..156909 + 321 WP_004456606.1 hypothetical protein -
M2J13_RS15960 156913..157299 + 387 WP_004456489.1 hypothetical protein -
M2J13_RS15965 157319..157741 + 423 WP_004456648.1 hypothetical protein -
M2J13_RS15970 157855..158085 + 231 WP_173706020.1 hypothetical protein -
M2J13_RS15975 158131..158442 + 312 WP_004456613.1 hypothetical protein -
M2J13_RS15980 158462..159052 + 591 WP_173706021.1 hypothetical protein Toxin
M2J13_RS15985 159033..159257 + 225 WP_004456691.1 hypothetical protein Antitoxin
M2J13_RS15990 159288..159530 - 243 WP_173706022.1 hypothetical protein -
M2J13_RS15995 159788..160288 - 501 WP_022071788.1 lincosamide nucleotidyltransferase Lnu(P) -
M2J13_RS16000 160370..161422 - 1053 WP_060795741.1 IS30 family transposase -
M2J13_RS16005 161668..162714 - 1047 WP_032492483.1 IS1595-like element ISCpe8 family transposase -
M2J13_RS16010 162800..163435 - 636 WP_173706023.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(Q) / erm(B) / aac(6')-aph(2'') / lnu(P) / erm(A) / optrA / fexA - 1..224659 224659


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RelA/SpoT

(57-159)

Antitoxin

Protein of unknown function DUF6718

(1-72)


Sequences

Toxin        


Download         Length: 197 a.a.        Molecular weight: 23493.87 Da        Isoelectric Point: 9.2173

>T273915 WP_173706021.1 NZ_CP119189:158462-159052 [Clostridium perfringens]
MIDISILDKLSYKSNLNKSLKNTLRKFNKEDIMTELLDIRGFYEKNQLLTTIKFDYRIKSFQSSLLKYDKYFPSTELKKC
FNDLLGFRIVIDNYNELDNISLENFRIADMRNGKANDDGYRGIHLYYQKSNRHYPIELQINTVKDRIFNDWLHQELYKYV
SNNNIGIELRKKYDDGIITSLEDFKGELKKHVLYNI

Download         Length: 591 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8547.92 Da        Isoelectric Point: 5.0178

>AT273915 WP_004456691.1 NZ_CP119189:159033-159257 [Clostridium perfringens]
MCYIISKKFNELGCYALKSELGDKLASLSRYLTLATLDKNVQIVTISDPNVYKEYEPYTFVISEKEFINKTLEL

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References