Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 93332..93857 Replicon plasmid p5
Accession NZ_CP119179
Organism Klebsiella pneumoniae strain X-CRHVKP-130

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag PY995_RS29060 Protein ID WP_001159871.1
Coordinates 93552..93857 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1PPD8
Locus tag PY995_RS29055 Protein ID WP_000813634.1
Coordinates 93332..93550 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY995_RS29030 (88663) 88663..88953 + 291 WP_000648897.1 hypothetical protein -
PY995_RS29035 (89526) 89526..90527 + 1002 WP_000785695.1 DUF4238 domain-containing protein -
PY995_RS29040 (90701) 90701..91045 - 345 WP_000792769.1 hypothetical protein -
PY995_RS29045 (91543) 91543..91797 - 255 WP_000678528.1 hypothetical protein -
PY995_RS29050 (91847) 91847..92773 - 927 WP_001290414.1 hypothetical protein -
PY995_RS29055 (93332) 93332..93550 + 219 WP_000813634.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PY995_RS29060 (93552) 93552..93857 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
PY995_RS29065 (93858) 93858..94292 + 435 Protein_107 tyrosine-type recombinase/integrase -
PY995_RS29070 (94357) 94357..95061 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
PY995_RS29075 (95113) 95113..95850 - 738 Protein_109 conjugal transfer protein TraB -
PY995_RS29080 (95850) 95850..96578 - 729 WP_001230787.1 type-F conjugative transfer system secretin TraK -
PY995_RS29085 (96565) 96565..97131 - 567 WP_000399794.1 type IV conjugative transfer system protein TraE -
PY995_RS29090 (97153) 97153..97464 - 312 WP_000012106.1 type IV conjugative transfer system protein TraL -
PY995_RS29095 (97479) 97479..97844 - 366 WP_021519752.1 type IV conjugative transfer system pilin TraA -
PY995_RS29100 (97878) 97878..98105 - 228 WP_001254386.1 conjugal transfer relaxosome protein TraY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid blaSHV-12 - 1..127419 127419
- flank IS/Tn - - 94357..95061 704


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T273909 WP_001159871.1 NZ_CP119179:93552-93857 [Klebsiella pneumoniae]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8372.34 Da        Isoelectric Point: 4.7405

>AT273909 WP_000813634.1 NZ_CP119179:93332-93550 [Klebsiella pneumoniae]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWKAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
PDB 3TCJ
PDB 2H3A
PDB 2ADN
PDB 2ADL
PDB 3HPW
PDB 2H3C
PDB 3G7Z
AlphaFold DB A0A829CQY2

References