Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5305605..5306230 Replicon chromosome
Accession NZ_CP119174
Organism Klebsiella pneumoniae strain X-CRHVKP-130

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag PY995_RS26160 Protein ID WP_002882817.1
Coordinates 5305605..5305988 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag PY995_RS26165 Protein ID WP_004150355.1
Coordinates 5305988..5306230 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY995_RS26145 (PY995_26145) 5302971..5303873 + 903 WP_002882822.1 formate dehydrogenase subunit beta -
PY995_RS26150 (PY995_26150) 5303870..5304505 + 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
PY995_RS26155 (PY995_26155) 5304502..5305431 + 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
PY995_RS26160 (PY995_26160) 5305605..5305988 - 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
PY995_RS26165 (PY995_26165) 5305988..5306230 - 243 WP_004150355.1 CopG family transcriptional regulator Antitoxin
PY995_RS26170 (PY995_26170) 5306435..5307352 + 918 WP_002882812.1 alpha/beta hydrolase -
PY995_RS26175 (PY995_26175) 5307366..5308307 - 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
PY995_RS26180 (PY995_26180) 5308352..5308789 - 438 WP_002882809.1 D-aminoacyl-tRNA deacylase -
PY995_RS26185 (PY995_26185) 5308786..5309646 - 861 WP_002882807.1 virulence factor BrkB family protein -
PY995_RS26190 (PY995_26190) 5309640..5310239 - 600 WP_004151865.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T273899 WP_002882817.1 NZ_CP119174:c5305988-5305605 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT273899 WP_004150355.1 NZ_CP119174:c5306230-5305988 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References