Detailed information of TA system TA273885

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): abiEi-abiEii/AbiEii-AbiEi
• Location: 1481684..1483116
• Replicon: chromosome
• Accession: NZ_CP119172
• Organism: Streptococcus macedonicus strain SGM CIP105683

Toxin (Protein)

• Gene name: abiEi
• Uniprot ID: A0A380JZZ2
• Locus tag: PY824_RS07775
• Protein ID: WP_039671050.1
• Coordinates: 1482271..1483116 (+)
• Length: 282 a.a.

Antitoxin (Protein)

• Gene name: abiEii
• Uniprot ID: A0A380K1K0
• Locus tag: PY824_RS07770
• Protein ID: WP_039671049.1
• Coordinates: 1481684..1482274 (+)
• Length: 197 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PY824_RS07770 (PY824_07770)	1481684..1482274	+	591	WP_039671049.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
PY824_RS07775 (PY824_07775)	1482271..1483116	+	846	WP_039671050.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PY824_RS07780 (PY824_07780)	1483280..1486081	-	2802	WP_115265882.1	phage tail tip lysozyme	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (33-258)

Antitoxin

• Transcriptional regulator, AbiEi antitoxin (6-50)

Sequences

Toxin

Protein

• Length: 282 a.a.
• Molecular weight: 32474.19 Da
• Isoelectric Point: 5.2246

>T273885 WP_039671050.1 NZ_CP119172:1482271-1483116 [Streptococcus macedonicus]
MNKAKLTALCHKISKNTGLTFNSVMTYYFLEVILKKLSQSTYSNHYIFKGGFLLSNVIGVESRSTVDIDFLFHQITLSED
TVKQQLKEILADSEEGISFVIQSITAIKESDDYGGYRATILCQLENIKQVIHLDIATGDVVTPQPITYDYKAIFDEENFP
IIAYTIETILAEKLQTIYSRNFLNSRSKDFYDVYILSKLKKEDIDFIQLKNACQRTFSYRETELDFEKIIELLERFKSDP
IQNKQWQNYSKKYSYTKGISLADVLDEMIRLIAVLISINSD

Nucleotide

• Length: 846 bp

Antitoxin

Protein

• Length: 197 a.a.
• Molecular weight: 23195.66 Da
• Isoelectric Point: 6.2569

>AT273885 WP_039671049.1 NZ_CP119172:1481684-1482274 [Streptococcus macedonicus]
MSKKEILLEFIENHNGIITYKDCKALNIPTIYLTRLEKEGILYRVEKGIFLTQNGDYDEYYFFQYRYPKAVFSYISALYL
QQFTDEIPQYFDVTIPRGYRFNTPPANLNIHSVSKENSELGITLVKTPMGNEVRAYDFERIICDFVIHREKIDTELFVKT
LQLYGNYPKKNLTKLYEYATKMNTLDKVEQTLEVLV

Nucleotide

• Length: 591 bp

Structures

Toxin

• AlphaFold DB: A0A380JZZ2

Antitoxin

• AlphaFold DB: A0A380K1K0