Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-HTH_XRE
Location 1462576..1463828 Replicon chromosome
Accession NZ_CP119172
Organism Streptococcus macedonicus strain SGM CIP105683

Toxin (Protein)


Gene name sezT Uniprot ID A0A380K1G8
Locus tag PY824_RS07700 Protein ID WP_039670298.1
Coordinates 1462576..1463352 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A380K1G9
Locus tag PY824_RS07705 Protein ID WP_039670297.1
Coordinates 1463352..1463828 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY824_RS07680 (PY824_07680) 1457783..1458679 - 897 WP_039671041.1 restriction endonuclease -
PY824_RS07685 (PY824_07685) 1458704..1461532 - 2829 WP_258927394.1 DEAD/DEAH box helicase -
PY824_RS07690 (PY824_07690) 1461577..1461786 - 210 WP_258927395.1 hypothetical protein -
PY824_RS07695 (PY824_07695) 1461783..1462592 - 810 WP_039670299.1 SAVED domain-containing protein -
PY824_RS07700 (PY824_07700) 1462576..1463352 - 777 WP_039670298.1 type II toxin-antitoxin system toxin PezT Toxin
PY824_RS07705 (PY824_07705) 1463352..1463828 - 477 WP_039670297.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
PY824_RS07710 (PY824_07710) 1463897..1464187 - 291 WP_039670296.1 hypothetical protein -
PY824_RS07715 (PY824_07715) 1464234..1464623 - 390 WP_039670295.1 DUF5945 family protein -
PY824_RS07720 (PY824_07720) 1464620..1464847 - 228 WP_039670294.1 DUF5965 family protein -
PY824_RS07725 (PY824_07725) 1464901..1465977 - 1077 WP_039670293.1 toprim domain-containing protein -
PY824_RS07730 (PY824_07730) 1466017..1466655 - 639 WP_039670292.1 hypothetical protein -
PY824_RS07735 (PY824_07735) 1466759..1468063 - 1305 WP_099421314.1 hypothetical protein -
PY824_RS07740 (PY824_07740) 1468194..1468523 - 330 WP_051673287.1 DUF5966 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1249269..1483105 233836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(27-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29327.26 Da        Isoelectric Point: 7.0541

>T273884 WP_039670298.1 NZ_CP119172:c1463352-1462576 [Streptococcus macedonicus]
MRLEEFSEAEFQKALQRTIRALTRGKTIPEQPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRKTAQLLRSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAINPNQARATPKKHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQECLFGKWSKIEEEML
RVGEGRMREMSKSNGKDA

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18289.82 Da        Isoelectric Point: 4.4758

>AT273884 WP_039670297.1 NZ_CP119172:c1463828-1463352 [Streptococcus macedonicus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSKVSTELIDCICQKFNVSYVDIVGEDKMLTPVEDYQLTLKIE
IIKERGAAILSKLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTFDEIERYNGYLDGIERMLDMVHHRVLA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380K1G8

Antitoxin

Source ID Structure
AlphaFold DB A0A380K1G9

References