Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1381153..1382405 Replicon chromosome
Accession NZ_CP119172
Organism Streptococcus macedonicus strain SGM CIP105683

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag PY824_RS07330 Protein ID WP_100262156.1
Coordinates 1381153..1381929 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag PY824_RS07335 Protein ID WP_100262157.1
Coordinates 1381929..1382405 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PY824_RS07320 (PY824_07320) 1377286..1379100 - 1815 WP_100262154.1 ATP-dependent helicase -
PY824_RS07325 (PY824_07325) 1379087..1381156 - 2070 WP_100262155.1 AAA family ATPase -
PY824_RS07330 (PY824_07330) 1381153..1381929 - 777 WP_100262156.1 type II toxin-antitoxin system toxin PezT Toxin
PY824_RS07335 (PY824_07335) 1381929..1382405 - 477 WP_100262157.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
PY824_RS07340 (PY824_07340) 1382475..1382765 - 291 WP_000667958.1 hypothetical protein -
PY824_RS07345 (PY824_07345) 1382814..1383203 - 390 WP_100262158.1 DUF5945 family protein -
PY824_RS07350 (PY824_07350) 1383200..1383427 - 228 WP_100262159.1 DUF5965 family protein -
PY824_RS07355 (PY824_07355) 1383481..1384557 - 1077 WP_100262160.1 toprim domain-containing protein -
PY824_RS07360 (PY824_07360) 1384597..1385235 - 639 WP_100262161.1 peptidylprolyl isomerase -
PY824_RS07365 (PY824_07365) 1385331..1385621 - 291 WP_100262162.1 DUF5966 family protein -
PY824_RS07370 (PY824_07370) 1385635..1385934 - 300 WP_014621288.1 DUF5962 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 1249269..1483105 233836


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29265.93 Da        Isoelectric Point: 5.6995

>T273883 WP_100262156.1 NZ_CP119172:c1381929-1381153 [Streptococcus macedonicus]
MRLEEFSEEEFQKALQRTIRTQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDNYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYGIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18213.58 Da        Isoelectric Point: 4.3971

>AT273883 WP_100262157.1 NZ_CP119172:c1382405-1381929 [Streptococcus macedonicus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTSDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References