Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | sezT-pezT/zeta-couple_hipB |
| Location | 1381153..1382405 | Replicon | chromosome |
| Accession | NZ_CP119172 | ||
| Organism | Streptococcus macedonicus strain SGM CIP105683 | ||
Toxin (Protein)
| Gene name | sezT | Uniprot ID | - |
| Locus tag | PY824_RS07330 | Protein ID | WP_100262156.1 |
| Coordinates | 1381153..1381929 (-) | Length | 259 a.a. |
Antitoxin (Protein)
| Gene name | pezT | Uniprot ID | - |
| Locus tag | PY824_RS07335 | Protein ID | WP_100262157.1 |
| Coordinates | 1381929..1382405 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PY824_RS07320 (PY824_07320) | 1377286..1379100 | - | 1815 | WP_100262154.1 | ATP-dependent helicase | - |
| PY824_RS07325 (PY824_07325) | 1379087..1381156 | - | 2070 | WP_100262155.1 | AAA family ATPase | - |
| PY824_RS07330 (PY824_07330) | 1381153..1381929 | - | 777 | WP_100262156.1 | type II toxin-antitoxin system toxin PezT | Toxin |
| PY824_RS07335 (PY824_07335) | 1381929..1382405 | - | 477 | WP_100262157.1 | type II toxin-antitoxin system antitoxin PezA | Antitoxin |
| PY824_RS07340 (PY824_07340) | 1382475..1382765 | - | 291 | WP_000667958.1 | hypothetical protein | - |
| PY824_RS07345 (PY824_07345) | 1382814..1383203 | - | 390 | WP_100262158.1 | DUF5945 family protein | - |
| PY824_RS07350 (PY824_07350) | 1383200..1383427 | - | 228 | WP_100262159.1 | DUF5965 family protein | - |
| PY824_RS07355 (PY824_07355) | 1383481..1384557 | - | 1077 | WP_100262160.1 | toprim domain-containing protein | - |
| PY824_RS07360 (PY824_07360) | 1384597..1385235 | - | 639 | WP_100262161.1 | peptidylprolyl isomerase | - |
| PY824_RS07365 (PY824_07365) | 1385331..1385621 | - | 291 | WP_100262162.1 | DUF5966 family protein | - |
| PY824_RS07370 (PY824_07370) | 1385635..1385934 | - | 300 | WP_014621288.1 | DUF5962 family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 1249269..1483105 | 233836 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 259 a.a. Molecular weight: 29265.93 Da Isoelectric Point: 5.6995
>T273883 WP_100262156.1 NZ_CP119172:c1381929-1381153 [Streptococcus macedonicus]
MRLEEFSEEEFQKALQRTIRTQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDNYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYGIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK
MRLEEFSEEEFQKALQRTIRTQSRGKTIPNQPRAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDNYRSQHPNYLALQD
KYGKDSVDYTKGFAGKMVEHLVDELSTQGYHLLIEGTLRTTQVPRQTAQLLSSKGYQVSLAVIGTKPELSYLSTLIRYEE
LYGIDPNQARATPKEHHDGIVENLVDNLKELESDKLFDQIQIYQRDRTCIYDSETDEGSAAEVLQNCLFGKWSKVEEEML
KVGQERLGELVSANGEKK
Download Length: 777 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18213.58 Da Isoelectric Point: 4.3971
>AT273883 WP_100262157.1 NZ_CP119172:c1382405-1381929 [Streptococcus macedonicus]
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTSDEIERYNGYLDGIERMLDMVHHRVVA
MIGDNIKSLRRTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDESNPWILMSDDLAELINTKIYLVDTSDEIERYNGYLDGIERMLDMVHHRVVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|