273881

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tad-ata/COG5606-COG4679
Location 4683883..4684549 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name tad Uniprot ID -
Locus tag P0S03_RS22860 Protein ID WP_134214823.1
Coordinates 4684190..4684549 (-) Length 120 a.a.

Antitoxin (Protein)


Gene name ata Uniprot ID -
Locus tag P0S03_RS22855 Protein ID WP_134214821.1
Coordinates 4683883..4684200 (-) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS22815 (4679171) 4679171..4679995 + 825 WP_048216971.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
P0S03_RS22820 (4680063) 4680063..4681286 + 1224 WP_003031639.1 L-sorbose 1-phosphate reductase -
P0S03_RS22825 (4681288) 4681288..4682100 + 813 WP_134214817.1 shikimate 5-dehydrogenase -
P0S03_RS22830 (4682134) 4682134..4682451 - 318 WP_054527950.1 CcdB family protein -
P0S03_RS22835 (4682451) 4682451..4682744 - 294 WP_003844689.1 type II toxin-antitoxin system CcdA family antitoxin -
P0S03_RS22840 (4682841) 4682841..4683206 - 366 WP_134214819.1 hypothetical protein -
P0S03_RS22845 (4683338) 4683338..4683511 + 174 WP_032938222.1 hypothetical protein -
P0S03_RS22850 (4683582) 4683582..4683743 + 162 WP_003841416.1 phage protein -
P0S03_RS22855 (4683883) 4683883..4684200 - 318 WP_134214821.1 helix-turn-helix transcriptional regulator Antitoxin
P0S03_RS22860 (4684190) 4684190..4684549 - 360 WP_134214823.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0S03_RS22865 (4684763) 4684763..4685452 + 690 WP_003841421.1 dipeptidase PepE -
P0S03_RS22870 (4685599) 4685599..4687230 - 1632 WP_003031618.1 Na/Pi cotransporter family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-87)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 13456.53 Da        Isoelectric Point: 10.2555

>T273881 WP_134214823.1 NZ_CP119165:c4684549-4684190 [Citrobacter freundii]
MTKPLYWVGQARKDLLAMPEHVRDTFGFAFWLAQQGKQHSQTKPLKGFGGAGVLEVVEDYHGSAWRAVYTIQLKNAVYVL
HVFQKKSVSGKATPKPEIDLIYQRLKAAQRHAQESGYVI

Download         Length: 360 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11504.44 Da        Isoelectric Point: 8.9375

>AT273881 WP_134214821.1 NZ_CP119165:c4684200-4683883 [Citrobacter freundii]
MSYEVEASSGNVYVDLGAYDAEQMQLKAQLAMVIGEILQRKGLTQQQAAQLLGMTQPKLSNLLRGQFRGISEAKMLECLV
RLGRDVEIVVGKEGNMSGKLKVKFG

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References