Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 3886740..3887419 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag P0S03_RS19080 Protein ID WP_172750876.1
Coordinates 3887078..3887419 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag P0S03_RS19075 Protein ID WP_127791922.1
Coordinates 3886740..3887057 (+) Length 106 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS19030 (3882181) 3882181..3883002 + 822 WP_172750878.1 DUF932 domain-containing protein -
P0S03_RS19035 (3883220) 3883220..3883921 + 702 WP_000189410.1 WYL domain-containing protein -
P0S03_RS19040 (3883958) 3883958..3884194 + 237 WP_001115854.1 protein YpjK -
P0S03_RS19045 (3884194) 3884194..3884637 + 444 WP_000824224.1 hypothetical protein -
P0S03_RS19050 (3884661) 3884661..3885128 + 468 WP_001446317.1 protein YkfB -
P0S03_RS19055 (3885205) 3885205..3885444 + 240 WP_000194654.1 DUF905 family protein -
P0S03_RS19060 (3885542) 3885542..3886000 + 459 WP_000211838.1 antirestriction protein -
P0S03_RS19065 (3886016) 3886016..3886492 + 477 WP_172750877.1 RadC family protein -
P0S03_RS19070 (3886501) 3886501..3886722 + 222 WP_125369006.1 DUF987 domain-containing protein -
P0S03_RS19075 (3886740) 3886740..3887057 + 318 WP_127791922.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
P0S03_RS19080 (3887078) 3887078..3887419 + 342 WP_172750876.1 type IV toxin-antitoxin system toxin YkfI Toxin
P0S03_RS19090 (3888041) 3888041..3888505 - 465 WP_003843778.1 isoprenylcysteine carboxylmethyltransferase family protein -
P0S03_RS19095 (3888698) 3888698..3890146 - 1449 WP_003838773.1 EAL domain-containing protein -
P0S03_RS19100 (3890488) 3890488..3890961 - 474 WP_003838775.1 hypothetical protein -
P0S03_RS19105 (3890936) 3890936..3891667 - 732 WP_016149623.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(5-104)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12946.02 Da        Isoelectric Point: 9.6543

>T273879 WP_172750876.1 NZ_CP119165:3887078-3887419 [Citrobacter freundii]
MKTLPATTQRAAKPCLSPVAVWQMLLTRLLEQHYGLTINDTPFCNEAVIKEHIDAGITLADAVNFLVEKYELVRIDRKGF
NWQEQSPYLRAVDILRARQPTGLLRQSRNNVVR

Download         Length: 342 bp

Antitoxin


Download         Length: 106 a.a.        Molecular weight: 11828.37 Da        Isoelectric Point: 6.3130

>AT273879 WP_127791922.1 NZ_CP119165:3886740-3887057 [Citrobacter freundii]
MNNTTWGLQRDITPRLGARLVQEGNRLHYLADRESITGKFSDAECLKLDVAFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFTCEADTLGSCGYVYIAIYPTQS

Download         Length: 318 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References