Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3684842..3685462 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag P0S03_RS18115 Protein ID WP_002892050.1
Coordinates 3685244..3685462 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag P0S03_RS18110 Protein ID WP_172750282.1
Coordinates 3684842..3685216 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS18100 (3679988) 3679988..3681181 + 1194 WP_003835922.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P0S03_RS18105 (3681204) 3681204..3684353 + 3150 WP_003021736.1 efflux RND transporter permease AcrB -
P0S03_RS18110 (3684842) 3684842..3685216 + 375 WP_172750282.1 Hha toxicity modulator TomB Antitoxin
P0S03_RS18115 (3685244) 3685244..3685462 + 219 WP_002892050.1 HHA domain-containing protein Toxin
P0S03_RS18120 (3685769) 3685769..3686320 + 552 WP_003835924.1 maltose O-acetyltransferase -
P0S03_RS18125 (3686437) 3686437..3686907 + 471 WP_003021724.1 YlaC family protein -
P0S03_RS18130 (3686986) 3686986..3687126 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
P0S03_RS18135 (3687128) 3687128..3687388 - 261 WP_003835926.1 type B 50S ribosomal protein L31 -
P0S03_RS18140 (3687592) 3687592..3689130 + 1539 WP_238788035.1 EAL domain-containing protein -
P0S03_RS18145 (3689182) 3689182..3689535 - 354 WP_003831033.1 DUF1428 family protein -
P0S03_RS18150 (3689600) 3689600..3690229 - 630 WP_016149709.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T273878 WP_002892050.1 NZ_CP119165:3685244-3685462 [Citrobacter freundii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14471.27 Da        Isoelectric Point: 5.5659

>AT273878 WP_172750282.1 NZ_CP119165:3684842-3685216 [Citrobacter freundii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRFFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References