273876

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2423667..2424306 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag P0S03_RS11955 Protein ID WP_071684398.1
Coordinates 2423667..2423843 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag P0S03_RS11960 Protein ID WP_123924900.1
Coordinates 2423890..2424306 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS11935 (2420445) 2420445..2420675 - 231 WP_003020233.1 DUF2554 family protein -
P0S03_RS11940 (2420865) 2420865..2420990 - 126 WP_003020230.1 DUF2474 domain-containing protein -
P0S03_RS11945 (2420990) 2420990..2422000 - 1011 WP_003020227.1 cytochrome d ubiquinol oxidase subunit II -
P0S03_RS11950 (2422000) 2422000..2423403 - 1404 WP_003020224.1 cytochrome ubiquinol oxidase subunit I -
P0S03_RS11955 (2423667) 2423667..2423843 + 177 WP_071684398.1 type II toxin-antitoxin system HicA family toxin Toxin
P0S03_RS11960 (2423890) 2423890..2424306 + 417 WP_123924900.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0S03_RS11965 (2424399) 2424399..2425808 + 1410 WP_172750337.1 PLP-dependent aminotransferase family protein -
P0S03_RS11970 (2426137) 2426137..2427282 + 1146 WP_061548295.1 ABC transporter substrate-binding protein -
P0S03_RS11975 (2427299) 2427299..2428315 + 1017 WP_003020210.1 ABC transporter ATP-binding protein -
P0S03_RS11980 (2428316) 2428316..2429260 + 945 WP_003843727.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-65)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6768.86 Da        Isoelectric Point: 11.6208

>T273876 WP_071684398.1 NZ_CP119165:2423667-2423843 [Citrobacter freundii]
VKQSKFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKAIIKQLDLQ

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15126.36 Da        Isoelectric Point: 4.5716

>AT273876 WP_123924900.1 NZ_CP119165:2423890-2424306 [Citrobacter freundii]
MRYPVTLTPAVEGGFVVSFPDIPEALTQGNTRHDALQAAQAALITAFEFYFDDNEAIPLPSAVSAEDDYVEIPLSVASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHTTKIDAVQIAARALGKELALTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References