Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872331..872985 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name cptA Uniprot ID A0A0J1NHY7
Locus tag P0S03_RS04315 Protein ID WP_003026936.1
Coordinates 872578..872985 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A6H3AT26
Locus tag P0S03_RS04310 Protein ID WP_003026938.1
Coordinates 872331..872597 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS04285 (867533) 867533..868966 - 1434 WP_044700805.1 6-phospho-beta-glucosidase BglA -
P0S03_RS04290 (869087) 869087..869815 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
P0S03_RS04295 (869868) 869868..870179 + 312 WP_044700802.1 N(4)-acetylcytidine aminohydrolase -
P0S03_RS04300 (870342) 870342..871001 + 660 WP_003026947.1 hemolysin III family protein -
P0S03_RS04305 (871095) 871095..872075 - 981 WP_119174530.1 tRNA-modifying protein YgfZ -
P0S03_RS04310 (872331) 872331..872597 + 267 WP_003026938.1 FAD assembly factor SdhE Antitoxin
P0S03_RS04315 (872578) 872578..872985 + 408 WP_003026936.1 protein YgfX Toxin
P0S03_RS04320 (873030) 873030..873551 - 522 WP_003026933.1 flavodoxin FldB -
P0S03_RS04325 (873665) 873665..874561 + 897 WP_003026928.1 site-specific tyrosine recombinase XerD -
P0S03_RS04330 (874585) 874585..875298 + 714 WP_003825520.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
P0S03_RS04335 (875304) 875304..877037 + 1734 WP_016150943.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15953.89 Da        Isoelectric Point: 11.4054

>T273871 WP_003026936.1 NZ_CP119165:872578-872985 [Citrobacter freundii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWSIVSAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLMLQKAKQK

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10558.09 Da        Isoelectric Point: 5.1700

>AT273871 WP_003026938.1 NZ_CP119165:872331-872597 [Citrobacter freundii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1NHY7

Antitoxin

Source ID Structure
AlphaFold DB A0A6H3AT26

References