Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 289618..290249 Replicon chromosome
Accession NZ_CP119165
Organism Citrobacter freundii strain 2075

Toxin (Protein)


Gene name hicA Uniprot ID A0A0J1MPQ6
Locus tag P0S03_RS01405 Protein ID WP_003837806.1
Coordinates 289618..289893 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0J1MMS0
Locus tag P0S03_RS01410 Protein ID WP_003837808.1
Coordinates 289890..290249 (+) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0S03_RS01395 (285669) 285669..288416 + 2748 WP_172750167.1 ribosome-associated ATPase/putative transporter RbbA -
P0S03_RS01400 (288416) 288416..289540 + 1125 WP_032950438.1 ABC transporter permease -
P0S03_RS01405 (289618) 289618..289893 + 276 WP_003837806.1 type II toxin-antitoxin system HicA family toxin Toxin
P0S03_RS01410 (289890) 289890..290249 + 360 WP_003837808.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
P0S03_RS01415 (290362) 290362..290763 - 402 WP_003023387.1 nickel-responsive transcriptional regulator NikR -
P0S03_RS01420 (290813) 290813..291391 - 579 WP_003837810.1 4'-phosphopantetheinyl transferase AcpT -
P0S03_RS01425 (291454) 291454..292503 - 1050 WP_003023393.1 AI-2E family transporter -
P0S03_RS01430 (292637) 292637..293854 + 1218 WP_003846164.1 MFS transporter -
P0S03_RS01435 (293858) 293858..294415 - 558 WP_003837816.1 DcrB family lipoprotein -
P0S03_RS01440 (294488) 294488..295153 - 666 WP_003837818.1 7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10210.88 Da        Isoelectric Point: 10.7228

>T273869 WP_003837806.1 NZ_CP119165:289618-289893 [Citrobacter freundii]
MKEKVLSLRKKQKNTLDQLFKAPTPQGIKWSEIESLIKALGGEIKEGRGSRCKFLLNKSIASFHRPHPSPDTDKGAVENV
RDWLTSIGVKP

Download         Length: 276 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13198.98 Da        Isoelectric Point: 4.5462

>AT273869 WP_003837808.1 NZ_CP119165:289890-290249 [Citrobacter freundii]
MIKPKTPNSMEIAGQPAVINYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGEISLREYLDDCSAAGIEPYANPEKLKT
FTLRYPESFGERLSFAAAEEQVSVNTWIIETLSKSLKQA

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J1MPQ6

Antitoxin

Source ID Structure
AlphaFold DB A0A0J1MMS0

References