Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 58344..58963 Replicon plasmid pCFSAN126951_03
Accession NZ_CP119162
Organism Enterococcus faecalis strain GENOMIC22-006

Toxin (Protein)


Gene name mazF Uniprot ID R3H4V2
Locus tag P0D81_RS17030 Protein ID WP_000241511.1
Coordinates 58601..58963 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID R3H5D1
Locus tag P0D81_RS17025 Protein ID WP_000245205.1
Coordinates 58344..58607 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D81_RS17005 (53843) 53843..56761 + 2919 WP_001240982.1 Tn3 family transposase -
P0D81_RS17010 (56874) 56874..57245 + 372 WP_010717384.1 IS3 family transposase -
P0D81_RS17015 (57270) 57270..57557 - 288 WP_010778046.1 hypothetical protein -
P0D81_RS17020 (57547) 57547..58167 - 621 WP_029656234.1 recombinase family protein -
P0D81_RS17025 (58344) 58344..58607 + 264 WP_000245205.1 PbsX family transcriptional regulator Antitoxin
P0D81_RS17030 (58601) 58601..58963 + 363 WP_000241511.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
P0D81_RS17035 (59028) 59028..59990 - 963 WP_002367770.1 LacI family DNA-binding transcriptional regulator -
P0D81_RS17040 (59992) 59992..61431 - 1440 WP_002367771.1 sucrose-6-phosphate hydrolase -
P0D81_RS17045 (61622) 61622..63553 + 1932 WP_275527570.1 sucrose-specific PTS transporter subunit IIBC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid erm(B) - 1..70159 70159


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin

Antitoxin PemI-like

(4-87)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13585.78 Da        Isoelectric Point: 9.6107

>T273868 WP_000241511.1 NZ_CP119162:58601-58963 [Enterococcus faecalis]
MVKVPHQGDILLLNTAPRSGHEQTGKRPYIVLSHDIIADYSNVVIVAPISSTKRNYPLYVSINPSYGMKTSGKVLLDQLT
TIDYEARQCVFLETAHEKLIDELLLKVRTVFQKVNKTNKF

Download         Length: 363 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10059.46 Da        Isoelectric Point: 5.1585

>AT273868 WP_000245205.1 NZ_CP119162:58344-58607 [Enterococcus faecalis]
MVMLSIKKWGNSNGLRLPKSVMEYLQIHTEDKVKITQEESNGKKRLIIEAVDSDNDLTIEQLFENYKEEKVHVTIQDLGN
AVGNEKW

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R3H4V2

Antitoxin

Source ID Structure
AlphaFold DB R3H5D1

References