273859

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ImmA-IrrE/HTH_26(antitoxin)
Location 728202..728900 Replicon chromosome
Accession NZ_CP119159
Organism Enterococcus faecalis strain GENOMIC22-006

Toxin (Protein)


Gene name IrrE Uniprot ID A0A059N529
Locus tag P0D81_RS03610 Protein ID WP_002373917.1
Coordinates 728202..728546 (-) Length 115 a.a.

Antitoxin (Protein)


Gene name ImmA Uniprot ID -
Locus tag P0D81_RS03615 Protein ID WP_002388206.1
Coordinates 728565..728900 (-) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D81_RS03590 (725438) 725438..725587 + 150 WP_002356321.1 50S ribosomal protein L33 -
P0D81_RS03595 (725690) 725690..726871 - 1182 WP_002365138.1 site-specific integrase -
P0D81_RS03600 (727026) 727026..727757 - 732 WP_010706861.1 potassium channel family protein -
P0D81_RS03605 (727775) 727775..728173 - 399 WP_010706860.1 hypothetical protein -
P0D81_RS03610 (728202) 728202..728546 - 345 WP_002373917.1 ImmA/IrrE family metallo-endopeptidase Toxin
P0D81_RS03615 (728565) 728565..728900 - 336 WP_002388206.1 helix-turn-helix transcriptional regulator Antitoxin
P0D81_RS03620 (729192) 729192..729374 + 183 WP_002388205.1 hypothetical protein -
P0D81_RS03625 (729387) 729387..729725 + 339 WP_010706859.1 hypothetical protein -
P0D81_RS03630 (729788) 729788..729967 + 180 WP_229202013.1 DUF2829 domain-containing protein -
P0D81_RS03635 (729985) 729985..730254 + 270 WP_002365131.1 hypothetical protein -
P0D81_RS03640 (730289) 730289..730459 + 171 WP_010706857.1 hypothetical protein -
P0D81_RS03645 (730460) 730460..730876 + 417 WP_002417286.1 hypothetical protein -
P0D81_RS03650 (730963) 730963..731262 + 300 WP_010706856.1 hypothetical protein -
P0D81_RS03655 (731259) 731259..731483 + 225 WP_002367281.1 hypothetical protein -
P0D81_RS03660 (731486) 731486..731842 + 357 WP_010706855.1 hypothetical protein -
P0D81_RS03665 (731935) 731935..732906 + 972 WP_010706854.1 RecT family recombinase -
P0D81_RS03670 (732869) 732869..733684 + 816 WP_010706853.1 PD-(D/E)XK nuclease-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 725690..776406 50716


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

IrrE N-terminal-like domain

(21-86)

Antitoxin

Cro/C1-type helix-turn-helix domain

(5-60)


Sequences

Toxin        


Download         Length: 115 a.a.        Molecular weight: 13594.61 Da        Isoelectric Point: 5.6177

>T273859 WP_002373917.1 NZ_CP119159:c728546-728202 [Enterococcus faecalis]
MKSIKELVEEYNVELVFTTLNKRACFDPTYGIIFVNQNLTPSEQEEAIYHELKHVKDHVDIMALYKIPVFRSKMEAEAEQ
YMFRSLIEKYEGQYNYSNVIAHYNLKMGQEIYLK

Download         Length: 345 bp

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12842.51 Da        Isoelectric Point: 5.2926

>AT273859 WP_002388206.1 NZ_CP119159:c728900-728565 [Enterococcus faecalis]
MTVFDRIKLLAKERGKSLNRIEEELGLPKNVLYRMKTSDNPTKDRLETLANYFDVSVDYLLGRTDNTKATDEKKSDDLDD
VLDNVMSFDGKPLDDHDREVIRAYLKGRFGK

Download         Length: 336 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A059N529

Antitoxin

Source ID Structure

References