Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 2706072..2706601 Replicon chromosome
Accession NZ_CP119150
Organism Enterococcus faecium strain GENOMIC22-005

Toxin (Protein)


Gene name relE Uniprot ID Q3XX67
Locus tag P0D82_RS13135 Protein ID WP_002296560.1
Coordinates 2706072..2706338 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A829F3T0
Locus tag P0D82_RS13140 Protein ID WP_002296559.1
Coordinates 2706338..2706601 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D82_RS13110 (P0D82_13110) 2701440..2702615 + 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -
P0D82_RS13115 (P0D82_13115) 2702619..2703260 + 642 WP_002293405.1 ABC transporter permease -
P0D82_RS13120 (P0D82_13120) 2703257..2704174 + 918 WP_002302664.1 osmoprotectant ABC transporter substrate-binding protein -
P0D82_RS13125 (P0D82_13125) 2704171..2704842 + 672 WP_002302663.1 ABC transporter permease -
P0D82_RS13130 (P0D82_13130) 2705383..2705871 - 489 WP_002296561.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
P0D82_RS13135 (P0D82_13135) 2706072..2706338 - 267 WP_002296560.1 Txe/YoeB family addiction module toxin Toxin
P0D82_RS13140 (P0D82_13140) 2706338..2706601 - 264 WP_002296559.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
P0D82_RS13145 (P0D82_13145) 2707077..2707262 + 186 WP_002296558.1 transcriptional regulator -
P0D82_RS13150 (P0D82_13150) 2707404..2709227 - 1824 WP_002294202.1 APC family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(9-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10660.13 Da        Isoelectric Point: 9.9931

>T273840 WP_002296560.1 NZ_CP119150:c2706338-2706072 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQTNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10046.05 Da        Isoelectric Point: 4.1207

>AT273840 WP_002296559.1 NZ_CP119150:c2706601-2706338 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSSFTNID
DIDWEAL

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FCW8

Antitoxin

Source ID Structure
AlphaFold DB A0A829F3T0

References