Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 6020732..6021366 Replicon chromosome
Accession NZ_CP119143
Organism Streptomyces sp. VNUA24

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYR72_RS25740 Protein ID WP_275457513.1
Coordinates 6020732..6021154 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PYR72_RS25745 Protein ID WP_275457514.1
Coordinates 6021151..6021366 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR72_RS25725 (PYR72_25725) 6017523..6020150 + 2628 WP_275457510.1 class III lanthionine synthetase LanKC -
PYR72_RS25730 (PYR72_25730) 6020162..6020410 + 249 WP_275457511.1 hypothetical protein -
PYR72_RS25735 (PYR72_25735) 6020425..6020682 + 258 WP_275457512.1 hypothetical protein -
PYR72_RS25740 (PYR72_25740) 6020732..6021154 - 423 WP_275457513.1 PIN domain nuclease Toxin
PYR72_RS25745 (PYR72_25745) 6021151..6021366 - 216 WP_275457514.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PYR72_RS25750 (PYR72_25750) 6021486..6023912 - 2427 WP_275457515.1 helicase-associated domain-containing protein -
PYR72_RS25755 (PYR72_25755) 6025333..6025653 + 321 WP_275457516.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-124)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(3-46)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 15360.24 Da        Isoelectric Point: 4.7222

>T273838 WP_275457513.1 NZ_CP119143:c6021154-6020732 [Streptomyces sp. VNUA24]
VNSAQFLIDTSALARFMREDAEQYGWDQAAAAGLIAACPITELEFFYSARSAADRARGIEDMRLIFGWVPVDDRAYDRAW
QVQEALTKQGKHRSAGAVDLVVAATAELQGLTLLHRDHDFACIAAVTGQALQWYGPESGK

Download         Length: 423 bp

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7805.84 Da        Isoelectric Point: 9.9912

>AT273838 WP_275457514.1 NZ_CP119143:c6021366-6021151 [Streptomyces sp. VNUA24]
VSRTVIDLDDDLVADVAKALGTSTKKETVNTALREVLESRRRALALARLRATATDGAFDLGLFENKGNYRR

Download         Length: 216 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References