273836

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 4310694..4311219 Replicon chromosome
Accession NZ_CP119143
Organism Streptomyces sp. VNUA24

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PYR72_RS18085 Protein ID WP_275456298.1
Coordinates 4310956..4311219 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PYR72_RS18080 Protein ID WP_275456297.1
Coordinates 4310694..4310963 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR72_RS18055 (PYR72_18055) 4305879..4307081 - 1203 WP_275456293.1 DUF4190 domain-containing protein -
PYR72_RS18060 (PYR72_18060) 4307338..4308447 + 1110 WP_275456294.1 threonine synthase -
PYR72_RS18065 (PYR72_18065) 4308441..4308614 - 174 WP_199845390.1 hypothetical protein -
PYR72_RS18070 (PYR72_18070) 4308789..4309418 + 630 WP_275456295.1 DUF6000 family protein -
PYR72_RS18075 (PYR72_18075) 4309443..4310546 - 1104 WP_275456296.1 hypothetical protein -
PYR72_RS18080 (PYR72_18080) 4310694..4310963 + 270 WP_275456297.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
PYR72_RS18085 (PYR72_18085) 4310956..4311219 + 264 WP_275456298.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PYR72_RS18090 (PYR72_18090) 4311354..4312442 - 1089 WP_013001094.1 redox-regulated ATPase YchF -
PYR72_RS18095 (PYR72_18095) 4312789..4313238 + 450 Protein_3600 hypothetical protein -
PYR72_RS18100 (PYR72_18100) 4313545..4314291 - 747 WP_275456299.1 ROK family protein -
PYR72_RS18105 (PYR72_18105) 4314433..4315434 - 1002 WP_275456300.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-58)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10058.46 Da        Isoelectric Point: 8.4578

>T273836 WP_275456298.1 NZ_CP119143:4310956-4311219 [Streptomyces sp. VNUA24]
VSEYRTVFRPEAQAELRKVPRDMALRILAKLTELESDPLGYNTTALVSQPDRRRLRVGDYRVLYTIDNGELVVWVVHVGH
RSTVYDS

Download         Length: 264 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10288.75 Da        Isoelectric Point: 4.7473

>AT273836 WP_275456297.1 NZ_CP119143:4310694-4310963 [Streptomyces sp. VNUA24]
MTQPLPIESIRDVRAHLAEVVERADRDDVPTVITRRGKQVAAVVSIEVLRKYQEWEEREINRIIDERMTNPAPGIPIEDI
MRETLARGE

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References