Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 959125..959780 Replicon plasmid p2022NG-0032_1
Accession NZ_CP119142
Organism Neisseria gonorrhoeae strain 2022NG-0032

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag P0D79_RS04960 Protein ID WP_003691083.1
Coordinates 959125..959544 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag P0D79_RS04965 Protein ID WP_003688410.1
Coordinates 959544..959780 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D79_RS04940 (P0D79_04940) 954359..955900 - 1542 WP_003697015.1 MDR family MFS transporter -
P0D79_RS04945 (P0D79_04945) 956048..956827 + 780 WP_041421436.1 (Fe-S)-binding protein -
P0D79_RS04950 (P0D79_04950) 956824..957525 + 702 WP_003688414.1 lactate utilization protein C -
P0D79_RS04955 (P0D79_04955) 957522..958976 + 1455 WP_003701282.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
P0D79_RS04960 (P0D79_04960) 959125..959544 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
P0D79_RS04965 (P0D79_04965) 959544..959780 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
P0D79_RS04970 (P0D79_04970) 960228..960806 - 579 WP_003688041.1 IS3 family transposase -
P0D79_RS04975 (P0D79_04975) 960811..961101 - 291 WP_041420764.1 helix-turn-helix domain-containing protein -
P0D79_RS04980 (P0D79_04980) 961451..961837 + 387 Protein_963 IS110 family transposase -
P0D79_RS04985 (P0D79_04985) 962220..963110 - 891 WP_002244992.1 succinate--CoA ligase subunit alpha -
P0D79_RS04990 (P0D79_04990) 963121..964287 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
P0D79_RS04995 (P0D79_04995) 964359..964646 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid penA pilQ / pilP / pilO / pilN / pilM / mntC / mntB / mntA / fbpC / fbpB / fbpA / nspA / lbpB / lbpB / lbpA / recN / pilT2 / pilZ / pilH / pilI / pilJ / pilK / pilX / pilW / kdsA / pilE / hmbR / hmbR / hmbR / mtrE / mtrD / mtrC / pilV / tbpA / tbpB / pilE / pilG / pilD / pilF / farB / farA / pilE / msrA/B / pilE / pilE / pilU / pilT / wbtL / tufA / tufA / porB / katA / lpt6 / htpB / luxS / hpuB / hpuA 1..2167441 2167441


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T273835 WP_003691083.1 NZ_CP119142:c959544-959125 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT273835 WP_003688410.1 NZ_CP119142:c959780-959544 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References