Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4635290..4635899 Replicon chromosome
Accession NZ_CP119138
Organism Alicyclobacillus fastidiosus strain Alicyclobacillus fastidiosus KKP 3000

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PYS47_RS22760 Protein ID WP_268005580.1
Coordinates 4635290..4635640 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag PYS47_RS22765 Protein ID WP_268008623.1
Coordinates 4635645..4635899 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYS47_RS22730 (PYS47_22730) 4630661..4630879 - 219 WP_275474389.1 DUF2922 domain-containing protein -
PYS47_RS22735 (PYS47_22735) 4630926..4631165 - 240 WP_275474390.1 DUF1659 domain-containing protein -
PYS47_RS22740 (PYS47_22740) 4631361..4632671 - 1311 WP_275474391.1 FtsW/RodA/SpoVE family cell cycle protein -
PYS47_RS22745 (PYS47_22745) 4632668..4632997 - 330 WP_275474392.1 helix-turn-helix transcriptional regulator -
PYS47_RS22750 (PYS47_22750) 4633178..4633915 - 738 WP_275474393.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
PYS47_RS22755 (PYS47_22755) 4633932..4635185 - 1254 WP_275474394.1 adenosylhomocysteinase -
PYS47_RS22760 (PYS47_22760) 4635290..4635640 - 351 WP_268005580.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PYS47_RS22765 (PYS47_22765) 4635645..4635899 - 255 WP_268008623.1 ribbon-helix-helix protein, CopG family Antitoxin
PYS47_RS22770 (PYS47_22770) 4635999..4637219 - 1221 WP_275474395.1 alanine racemase -
PYS47_RS22775 (PYS47_22775) 4637409..4638407 - 999 WP_275477040.1 outer membrane lipoprotein carrier protein LolA -
PYS47_RS22780 (PYS47_22780) 4638449..4639933 - 1485 WP_275474396.1 NAD(P)H-hydrate dehydratase -
PYS47_RS22785 (PYS47_22785) 4640027..4640404 - 378 WP_275474397.1 holo-ACP synthase -
PYS47_RS22790 (PYS47_22790) 4640538..4640726 + 189 WP_275474398.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-110)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-36)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12843.95 Da        Isoelectric Point: 5.6766

>T273832 WP_268005580.1 NZ_CP119138:c4635640-4635290 [Alicyclobacillus fastidiosus]
MNVKRGDVFFADLSPVVGSEQGGFRPVLIIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIPAQPYGLERDSVVLLEQL
RTLDKQRLTDKITHLDDTMMKMVNDGLLISLGLVDF

Download         Length: 351 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9597.88 Da        Isoelectric Point: 4.8090

>AT273832 WP_268008623.1 NZ_CP119138:c4635899-4635645 [Alicyclobacillus fastidiosus]
MVVYVPEQLLEQVDGFARTDSANRSEIVREALRMYVTAHRKNDIREQMQQGYLEMARLNLRIASESFPLEQEAGGTVERL
VSGV

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References