Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4031255..4031771 Replicon chromosome
Accession NZ_CP119137
Organism Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792

Toxin (Protein)


Gene name relE Uniprot ID A0A3V5VNJ7
Locus tag P0D85_RS20515 Protein ID WP_000220577.1
Coordinates 4031255..4031539 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag P0D85_RS20520 Protein ID WP_000212724.1
Coordinates 4031529..4031771 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D85_RS20500 (4026467) 4026467..4028119 + 1653 WP_126524329.1 alpha,alpha-phosphotrehalase -
P0D85_RS20505 (4028528) 4028528..4030666 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
P0D85_RS20510 (4030787) 4030787..4031251 + 465 WP_031605772.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
P0D85_RS20515 (4031255) 4031255..4031539 - 285 WP_000220577.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
P0D85_RS20520 (4031529) 4031529..4031771 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
P0D85_RS20525 (4031849) 4031849..4033762 - 1914 WP_140902122.1 BglG family transcription antiterminator -
P0D85_RS20530 (4033779) 4033779..4034519 - 741 WP_126524331.1 KDGP aldolase family protein -
P0D85_RS20535 (4034516) 4034516..4035634 - 1119 WP_126524332.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
P0D85_RS20540 (4035618) 4035618..4036751 - 1134 WP_126524333.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.71 Da        Isoelectric Point: 9.8739

>T273829 WP_000220577.1 NZ_CP119137:c4031539-4031255 [Salmonella enterica subsp. enterica serovar Goldcoast]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT273829 WP_000212724.1 NZ_CP119137:c4031771-4031529 [Salmonella enterica subsp. enterica serovar Goldcoast]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V5VNJ7

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References