Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3344984..3345604 Replicon chromosome
Accession NZ_CP119137
Organism Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag P0D85_RS17385 Protein ID WP_001280991.1
Coordinates 3345386..3345604 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag P0D85_RS17380 Protein ID WP_000344807.1
Coordinates 3344984..3345358 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D85_RS17370 (3340123) 3340123..3341316 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
P0D85_RS17375 (3341339) 3341339..3344488 + 3150 WP_126524222.1 efflux RND transporter permease AcrB -
P0D85_RS17380 (3344984) 3344984..3345358 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
P0D85_RS17385 (3345386) 3345386..3345604 + 219 WP_001280991.1 HHA domain-containing protein Toxin
P0D85_RS17390 (3345783) 3345783..3346334 + 552 WP_001278793.1 maltose O-acetyltransferase -
P0D85_RS17395 (3346452) 3346452..3346922 + 471 WP_126524223.1 YlaC family protein -
P0D85_RS17400 (3346978) 3346978..3347118 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
P0D85_RS17405 (3347120) 3347120..3347383 - 264 WP_000801416.1 type B 50S ribosomal protein L31 -
P0D85_RS17410 (3347608) 3347608..3349158 + 1551 WP_126524224.1 EAL domain-containing protein -
P0D85_RS17420 (3349389) 3349389..3349778 + 390 WP_126524225.1 MGMT family protein -
P0D85_RS17425 (3349811) 3349811..3350380 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T273826 WP_001280991.1 NZ_CP119137:3345386-3345604 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT273826 WP_000344807.1 NZ_CP119137:3344984-3345358 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References