Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 9776..11399 Replicon plasmid pSal02792
Accession NZ_CP119136
Organism Salmonella enterica subsp. enterica serovar Goldcoast isolate Sal02792

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag P0D85_RS00075 Protein ID WP_000088046.1
Coordinates 10074..11399 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag P0D85_RS00070 Protein ID WP_024136327.1
Coordinates 9776..10069 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
P0D85_RS00040 (P0D85_00040) 5648..6889 + 1242 WP_001053338.1 VWA domain-containing protein -
P0D85_RS00045 (P0D85_00045) 6980..7111 + 132 WP_000374059.1 hypothetical protein -
P0D85_RS00050 (P0D85_00050) 7452..7733 - 282 WP_000077926.1 hypothetical protein -
P0D85_RS00055 (P0D85_00055) 7783..7974 - 192 WP_000398480.1 hypothetical protein -
P0D85_RS00060 (P0D85_00060) 8066..8407 - 342 WP_001151575.1 hypothetical protein -
P0D85_RS00065 (P0D85_00065) 8780..9172 + 393 WP_000341066.1 hypothetical protein -
P0D85_RS00070 (P0D85_00070) 9776..10069 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
P0D85_RS00075 (P0D85_00075) 10074..11399 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
P0D85_RS00080 (P0D85_00080) 11460..11666 + 207 WP_000134171.1 hypothetical protein -
P0D85_RS00085 (P0D85_00085) 11768..12178 + 411 WP_000985911.1 hypothetical protein -
P0D85_RS00090 (P0D85_00090) 12191..13006 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
P0D85_RS00095 (P0D85_00095) 13260..13436 + 177 WP_164848126.1 hypothetical protein -
P0D85_RS00100 (P0D85_00100) 13473..14177 + 705 WP_001067855.1 IS6-like element IS26 family transposase -
P0D85_RS00105 (P0D85_00105) 14228..14458 + 231 Protein_20 IS1 family transposase -
P0D85_RS00110 (P0D85_00110) 14604..14861 + 258 WP_105278499.1 hypothetical protein -
P0D85_RS00115 (P0D85_00115) 14898..15866 - 969 WP_077783444.1 IS5 family transposase -
P0D85_RS00120 (P0D85_00120) 15901..16176 + 276 Protein_23 peptidoglycan DD-metalloendopeptidase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid blaTEM-1B / sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / qnrS1 / oqxA / oqxB / aac(3)-IIa / mph(A) / sul1 / qacE / aadA5 / dfrA17 - 1..237330 237330
- flank IS/Tn - - 14898..15866 968


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T273816 WP_000088046.1 NZ_CP119136:10074-11399 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT273816 WP_024136327.1 NZ_CP119136:9776-10069 [Salmonella enterica subsp. enterica serovar Goldcoast]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References