Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/Txe-YefM
Location 6504642..6505168 Replicon chromosome
Accession NZ_CP119133
Organism Streptomyces sp. FXJ1.172

Toxin (Protein)


Gene name relE Uniprot ID A0A176LAJ8
Locus tag A6P39_RS29125 Protein ID WP_067040802.1
Coordinates 6504642..6504899 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1H5P6W5
Locus tag A6P39_RS29130 Protein ID WP_067040800.1
Coordinates 6504896..6505168 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
A6P39_RS29105 (A6P39_029105) 6501508..6502092 - 585 WP_275883990.1 ATP-binding protein -
A6P39_RS29110 (A6P39_029110) 6502300..6503130 + 831 WP_067040807.1 helix-turn-helix transcriptional regulator -
A6P39_RS29115 (A6P39_029115) 6503127..6503330 + 204 WP_067040805.1 DUF397 domain-containing protein -
A6P39_RS29120 (A6P39_029120) 6503601..6504332 - 732 WP_067040803.1 hypothetical protein -
A6P39_RS29125 (A6P39_029125) 6504642..6504899 - 258 WP_067040802.1 Txe/YoeB family addiction module toxin Toxin
A6P39_RS29130 (A6P39_029130) 6504896..6505168 - 273 WP_067040800.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
A6P39_RS29135 (A6P39_029135) 6505325..6505963 - 639 WP_067040797.1 hypothetical protein -
A6P39_RS29140 (A6P39_029140) 6505956..6506225 - 270 WP_067040794.1 hypothetical protein -
A6P39_RS29145 (A6P39_029145) 6506453..6506863 + 411 WP_067040791.1 hypothetical protein -
A6P39_RS29150 (A6P39_029150) 6506872..6509013 + 2142 WP_234378758.1 tetratricopeptide repeat protein -
A6P39_RS29155 (A6P39_029155) 6509104..6509301 + 198 WP_159395970.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(6-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(2-71)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10117.58 Da        Isoelectric Point: 10.3604

>T273815 WP_067040802.1 NZ_CP119133:c6504899-6504642 [Streptomyces sp. FXJ1.172]
VRSVHFDPAAWEDFLFRLGSDRGMARRITRLIAEVQRTPFTGIGKPEPLKSDLSGYWSRRIDDEHRLVYRVNEKEVKILK
ARYHY

Download         Length: 258 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 9884.08 Da        Isoelectric Point: 4.4978

>AT273815 WP_067040800.1 NZ_CP119133:c6505168-6504896 [Streptomyces sp. FXJ1.172]
MTISASEARKDLFPLIKRVNDDHTPVRISSKSGDAVLMSAEDYDSWQETVYLLRSPANARSLMEAVARDRAGEAVVTRTM
AELEELAGDG

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A176LAJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1H5P6W5

References