Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 404..936 Replicon plasmid unnamed4
Accession NZ_CP119131
Organism Sphingobium sp. WTD-1

Toxin (Protein)


Gene name parE Uniprot ID A0A1M6P9W1
Locus tag N6H05_RS28105 Protein ID WP_037477193.1
Coordinates 649..936 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1M6PAC9
Locus tag N6H05_RS28100 Protein ID WP_037477190.1
Coordinates 404..652 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H05_RS28100 (N6H05_28100) 404..652 + 249 WP_037477190.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
N6H05_RS28105 (N6H05_28105) 649..936 + 288 WP_037477193.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6H05_RS28110 (N6H05_28110) 941..1507 - 567 WP_037477195.1 hypothetical protein -
N6H05_RS28115 (N6H05_28115) 1504..1770 - 267 WP_052027734.1 hypothetical protein -
N6H05_RS28120 (N6H05_28120) 1924..3165 + 1242 WP_060610909.1 MobQ family relaxase -
N6H05_RS28125 (N6H05_28125) 3524..4855 + 1332 WP_037479041.1 hypothetical protein -
N6H05_RS28130 (N6H05_28130) 4888..5280 - 393 WP_037477185.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..6362 6362


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-90)

Antitoxin

Antitoxin ParD

(1-78)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10875.07 Da        Isoelectric Point: 6.8605

>T273814 WP_037477193.1 NZ_CP119131:649-936 [Sphingobium sp. WTD-1]
MKALSFSPRAEVDIDGIWDYSADNWGPDQADRYTDEIRDACHALASGRKQGRATNVRLGYRKCPTGSHVIYFRDRGDWLE
IVRVLHSAQDAERHL

Download         Length: 288 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9201.32 Da        Isoelectric Point: 5.7202

>AT273814 WP_037477190.1 NZ_CP119131:404-652 [Sphingobium sp. WTD-1]
MARNTSVSLGDHFTTFIDMQVQAGRYGSASDVVRAGLRLLQEHEAKVKALEVALIEGEESGEPQPFDFEAFKKRKRAEYE
GR

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M6P9W1

Antitoxin

Source ID Structure
AlphaFold DB A0A1M6PAC9

References