Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 400605..401107 Replicon plasmid unnamed1
Accession NZ_CP119128
Organism Sphingobium sp. WTD-1

Toxin (Protein)


Gene name yoeB Uniprot ID Q5XQD8
Locus tag N6H05_RS27130 Protein ID WP_032492620.1
Coordinates 400853..401107 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1V0BEH6
Locus tag N6H05_RS27125 Protein ID WP_032492621.1
Coordinates 400605..400856 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H05_RS27105 (N6H05_27105) 396358..397575 + 1218 WP_006122485.1 TniQ family protein -
N6H05_RS27110 (N6H05_27110) 397637..398260 + 624 WP_003155741.1 recombinase family protein -
N6H05_RS27115 (N6H05_27115) 398332..399495 - 1164 WP_048709300.1 class C beta-lactamase -
N6H05_RS27120 (N6H05_27120) 399789..400421 - 633 WP_000186237.1 type B-3 chloramphenicol O-acetyltransferase CatB3 -
N6H05_RS27125 (N6H05_27125) 400605..400856 + 252 WP_032492621.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
N6H05_RS27130 (N6H05_27130) 400853..401107 + 255 WP_032492620.1 Txe/YoeB family addiction module toxin Toxin
N6H05_RS27135 (N6H05_27135) 401180..401734 - 555 WP_012695458.1 AAC(6')-Ib family aminoglycoside 6'-N-acetyltransferase -
N6H05_RS27140 (N6H05_27140) 401863..402099 - 237 WP_024167031.1 trimethoprim-resistant dihydrofolate reductase DfrB4 -
N6H05_RS27145 (N6H05_27145) 402303..403316 + 1014 WP_000845048.1 class 1 integron integrase IntI1 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catB3 / dfrB4 virB11 1..449985 449985
- inside IScluster/Tn catB3 / dfrB4 - 392974..406505 13531
- inside Integron catB3 / dfrB4 - 399735..403316 3581


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10272.81 Da        Isoelectric Point: 9.3585

>T273812 WP_032492620.1 NZ_CP119128:400853-401107 [Sphingobium sp. WTD-1]
MRLIFSDDAWEDYLFWQKQDRRMVDRINKLIKETTREPFSGVGKPEPLKHALAGYWSRRITDEHRMVYKVADDALWIVQL
KYHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9244.40 Da        Isoelectric Point: 4.7769

>AT273812 WP_032492621.1 NZ_CP119128:400605-400856 [Sphingobium sp. WTD-1]
MDAITYTHARANLAGTMDRVCNDHEPVIITRNGDQSVVILSLEDFQALEETAYLLRSPANAKRLFKSIEQLEAGRGQARE
LAE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1V0BEH9

Antitoxin

Source ID Structure
AlphaFold DB A0A1V0BEH6

References