Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 366221..366752 Replicon plasmid unnamed1
Accession NZ_CP119128
Organism Sphingobium sp. WTD-1

Toxin (Protein)


Gene name relE Uniprot ID T0GNF5
Locus tag N6H05_RS26940 Protein ID WP_004212690.1
Coordinates 366221..366502 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID T0G968
Locus tag N6H05_RS26945 Protein ID WP_004212689.1
Coordinates 366489..366752 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H05_RS26915 (N6H05_26915) 361740..362147 + 408 WP_016743851.1 response regulator -
N6H05_RS26920 (N6H05_26920) 362210..363178 - 969 Protein_355 magnesium/cobalt transporter CorA -
N6H05_RS26925 (N6H05_26925) 363627..364457 - 831 WP_021245217.1 SDR family oxidoreductase -
N6H05_RS26930 (N6H05_26930) 364527..365093 + 567 WP_062787982.1 TetR family transcriptional regulator -
N6H05_RS26935 (N6H05_26935) 365301..365873 - 573 WP_284114374.1 PepSY-associated TM helix domain-containing protein -
N6H05_RS26940 (N6H05_26940) 366221..366502 - 282 WP_004212690.1 type II toxin-antitoxin system YafQ family toxin Toxin
N6H05_RS26945 (N6H05_26945) 366489..366752 - 264 WP_004212689.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N6H05_RS26950 (N6H05_26950) 367137..367574 - 438 WP_007683347.1 DUF411 domain-containing protein -
N6H05_RS26955 (N6H05_26955) 367654..368895 - 1242 WP_007683345.1 MFS transporter -
N6H05_RS26960 (N6H05_26960) 368889..369875 - 987 WP_284114376.1 copper resistance protein B -
N6H05_RS26965 (N6H05_26965) 369872..371578 - 1707 WP_062788780.1 copper resistance system multicopper oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid catB3 / dfrB4 virB11 1..449985 449985


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(1-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-76)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10993.49 Da        Isoelectric Point: 7.4752

>T273811 WP_004212690.1 NZ_CP119128:c366502-366221 [Sphingobium sp. WTD-1]
MRTIERFGRFKRDYKREKKGQHAKTLDADLIPIIEALASDEPLEPRHRDHALTGDWRDHRDCHIKPDLVLIYRKPDDDTL
QLVRLGSHAELGW

Download         Length: 282 bp

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9284.75 Da        Isoelectric Point: 4.5881

>AT273811 WP_004212689.1 NZ_CP119128:c366752-366489 [Sphingobium sp. WTD-1]
MAANALVQTRIDGAVKEEAATVLAAMGLTVSDAVRLMLTRVARDKALPFEPLVPNAETIEAMKEAREGKGKRFATVVDLM
ADLNADD

Download         Length: 264 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB T0GNF5

Antitoxin

Source ID Structure
AlphaFold DB T0G968

References