Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 4764283..4764895 Replicon chromosome
Accession NZ_CP119127
Organism Sphingobium sp. WTD-1

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag N6H05_RS23640 Protein ID WP_284111933.1
Coordinates 4764605..4764895 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID A0A085KAU2
Locus tag N6H05_RS23635 Protein ID WP_037506112.1
Coordinates 4764283..4764570 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N6H05_RS23615 (N6H05_23615) 4759553..4760359 - 807 WP_007713350.1 LytTR family DNA-binding domain-containing protein -
N6H05_RS23620 (N6H05_23620) 4760356..4761462 - 1107 WP_284111931.1 histidine kinase -
N6H05_RS23625 (N6H05_23625) 4761518..4762000 - 483 WP_010336740.1 helix-turn-helix domain-containing protein -
N6H05_RS23630 (N6H05_23630) 4762122..4764227 + 2106 WP_284111932.1 bifunctional (p)ppGpp synthetase/guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase -
N6H05_RS23635 (N6H05_23635) 4764283..4764570 - 288 WP_037506112.1 putative addiction module antidote protein Antitoxin
N6H05_RS23640 (N6H05_23640) 4764605..4764895 - 291 WP_284111933.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N6H05_RS23645 (N6H05_23645) 4765269..4765784 + 516 WP_284111934.1 50S ribosomal protein L10 -
N6H05_RS23650 (N6H05_23650) 4765857..4766231 + 375 WP_004210471.1 50S ribosomal protein L7/L12 -
N6H05_RS23655 (N6H05_23655) 4766401..4767828 + 1428 WP_284111935.1 carboxylesterase family protein -
N6H05_RS23660 (N6H05_23660) 4767838..4769313 - 1476 WP_284111936.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-94)

Antitoxin

Uncharacterized protein HI1420

(4-91)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10675.39 Da        Isoelectric Point: 10.5317

>T273810 WP_284111933.1 NZ_CP119127:c4764895-4764605 [Sphingobium sp. WTD-1]
MEVLQTPVFAEWFAALRDRRARSKIAGRIARFELGLLGDVKSVGDGVLEARVDFGPGYRLYCVRRGDRLIVLLVGGDKSS
QPRDIARAKDMAARID

Download         Length: 291 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10149.81 Da        Isoelectric Point: 5.6492

>AT273810 WP_037506112.1 NZ_CP119127:c4764570-4764283 [Sphingobium sp. WTD-1]
MTIELTRFDAAEALTQAEDQAELLADAFATGDVHVITQAIGIVARAHGMTELAKATGMKRQQLYRMLGPDGNPTLGSMLK
LLPALGLRMRIEAAA

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A085KAU2

References