273804

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsxAB/MqsA(antitoxin)
Location 2899..3364 Replicon plasmid pCFSAN126949_05
Accession NZ_CP119125
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name TsxA Uniprot ID U9ZUY2
Locus tag PYZ88_RS25330 Protein ID WP_001230707.1
Coordinates 3113..3364 (-) Length 84 a.a.

Antitoxin (Protein)


Gene name TsxB Uniprot ID M7CCF8
Locus tag PYZ88_RS25325 Protein ID WP_000801440.1
Coordinates 2899..3126 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS25300 (PYZ88_25260) 77..580 - 504 WP_000781813.1 relaxosome-coupling protein TaxA -
PYZ88_RS25305 (PYZ88_25265) 936..1067 - 132 WP_001353745.1 toxin-antitoxin system HicB family antitoxin -
PYZ88_RS25310 (PYZ88_25270) 1412..1705 - 294 WP_044344513.1 hypothetical protein -
PYZ88_RS25315 (PYZ88_25275) 1720..2094 - 375 WP_000844303.1 tail-associated lysozyme -
PYZ88_RS25320 (PYZ88_25280) 2146..2445 - 300 WP_000650311.1 hypothetical protein -
PYZ88_RS25325 (PYZ88_25285) 2899..3126 - 228 WP_000801440.1 hypothetical protein Antitoxin
PYZ88_RS25330 (PYZ88_25290) 3113..3364 - 252 WP_001230707.1 hypothetical protein Toxin
PYZ88_RS25335 (PYZ88_25295) 3361..3903 - 543 WP_001083906.1 hypothetical protein -
PYZ88_RS25340 (PYZ88_25300) 4008..4523 - 516 WP_001025395.1 J domain-containing protein -
PYZ88_RS25345 (PYZ88_25305) 5163..5513 - 351 WP_000127482.1 addiction module antitoxin -
PYZ88_RS25350 (PYZ88_25310) 5510..5845 - 336 WP_001147119.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..37257 37257


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 84 a.a.        Molecular weight: 9751.13 Da        Isoelectric Point: 8.9187

>T273804 WP_001230707.1 NZ_CP119125:c3364-3113 [Escherichia coli]
MRKNKGDVTYFLEKEGDNYRLTKRIKARTNVKIGNKTTKITLYDAVLNENELQHIDFTCAGLREDDETPVKNLIKEFMLN
ETR

Download         Length: 252 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8659.98 Da        Isoelectric Point: 8.5105

>AT273804 WP_000801440.1 NZ_CP119125:c3126-2899 [Escherichia coli]
MKPDNTPENVKKLRLKAGLTQKECSHIYGVGLRTWQKKEEVNTQNSQSLSLVEFEFLLLLAGEHPEYVLCKRESK

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9ZUY2

Antitoxin

Source ID Structure
AlphaFold DB A0A5Y6U8W9

References