Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1093..1618 Replicon plasmid pCFSAN126949_02
Accession NZ_CP119123
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name ccdB Uniprot ID S1PFV8
Locus tag PYZ88_RS24755 Protein ID WP_001159871.1
Coordinates 1313..1618 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H9TJP1
Locus tag PYZ88_RS24750 Protein ID WP_000813630.1
Coordinates 1093..1311 (+) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS24745 (303) 303..533 - 231 WP_001261286.1 type II toxin-antitoxin system VapB family antitoxin -
PYZ88_RS24750 (1093) 1093..1311 + 219 WP_000813630.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
PYZ88_RS24755 (1313) 1313..1618 + 306 WP_001159871.1 type II toxin-antitoxin system toxin CcdB Toxin
PYZ88_RS24760 (1619) 1619..2425 + 807 WP_000016970.1 site-specific integrase -
PYZ88_RS24765 (3147) 3147..3902 + 756 WP_000852146.1 replication initiation protein RepE -
PYZ88_RS24770 (4490) 4490..5656 + 1167 WP_000772446.1 plasmid-partitioning protein SopA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sitABCD iucA / iucB / iucC / iucD / iutA 1..83235 83235


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11692.49 Da        Isoelectric Point: 6.4674

>T273799 WP_001159871.1 NZ_CP119123:1313-1618 [Escherichia coli]
MQFKVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHVGDESWRMMTTDMASVPVSVIGEEV
ADLSHRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8354.27 Da        Isoelectric Point: 4.5203

>AT273799 WP_000813630.1 NZ_CP119123:1093-1311 [Escherichia coli]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTLQNEARRLRAERWQAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CCE8

Antitoxin

Source ID Structure
AlphaFold DB A0A829CEF5

References