Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 4478016..4478602 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag PYZ88_RS21910 Protein ID WP_042014162.1
Coordinates 4478372..4478602 (-) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag PYZ88_RS21905 Protein ID WP_000593555.1
Coordinates 4478016..4478375 (-) Length 120 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS21880 (4474148) 4474148..4475092 + 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -
PYZ88_RS21885 (4475089) 4475089..4475922 + 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
PYZ88_RS21890 (4475922) 4475922..4476686 + 765 WP_001136236.1 nickel import ATP-binding protein NikD -
PYZ88_RS21895 (4476683) 4476683..4477489 + 807 WP_000173666.1 nickel import ATP-binding protein NikE -
PYZ88_RS21900 (4477495) 4477495..4477896 + 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
PYZ88_RS21905 (4478016) 4478016..4478375 - 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
PYZ88_RS21910 (4478372) 4478372..4478602 - 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
PYZ88_RS21915 (4478706) 4478706..4479830 - 1125 WP_001314210.1 ABC transporter permease -
PYZ88_RS21920 (4479830) 4479830..4482565 - 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(15-65)

Antitoxin

Uncharacterised protein family HicB

(60-112)


Sequences

Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T273797 WP_042014162.1 NZ_CP119120:c4478602-4478372 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp

Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT273797 WP_000593555.1 NZ_CP119120:c4478375-4478016 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References