Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4456511..4457311 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name ataT Uniprot ID F4NNI0
Locus tag PYZ88_RS21785 Protein ID WP_000342449.1
Coordinates 4456511..4457038 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID F4NNI1
Locus tag PYZ88_RS21790 Protein ID WP_001277108.1
Coordinates 4457045..4457311 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS21760 (4451586) 4451586..4452353 - 768 WP_000082101.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
PYZ88_RS21765 (4452350) 4452350..4453627 - 1278 WP_000803799.1 branched chain amino acid ABC transporter permease LivM -
PYZ88_RS21770 (4453624) 4453624..4454550 - 927 WP_000003004.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
PYZ88_RS21775 (4454598) 4454598..4455707 - 1110 WP_000827696.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
PYZ88_RS21780 (4456131) 4456131..4456514 + 384 WP_000778781.1 aspartate 1-decarboxylase autocleavage activator PanM -
PYZ88_RS21785 (4456511) 4456511..4457038 - 528 WP_000342449.1 type II toxin-antitoxin system toxin acetyltransferase AtaT Toxin
PYZ88_RS21790 (4457045) 4457045..4457311 - 267 WP_001277108.1 type II toxin-antitoxin system antitoxin AtaR Antitoxin
PYZ88_RS21795 (4457461) 4457461..4458564 - 1104 WP_001350438.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
PYZ88_RS21800 (4458836) 4458836..4459690 - 855 WP_000130217.1 RNA polymerase sigma factor RpoH -
PYZ88_RS21805 (4459935) 4459935..4460993 - 1059 WP_001042003.1 permease-like cell division protein FtsX -
PYZ88_RS21810 (4460986) 4460986..4461654 - 669 WP_000617723.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(88-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19691.70 Da        Isoelectric Point: 7.7457

>T273796 WP_000342449.1 NZ_CP119120:c4457038-4456511 [Escherichia coli]
MDDLTIEILTDDADYDLQRFDCGEEALNLFLTTHLVRQHRNKILRAYILCRNTPERQVLGYYTLCGSCFERAALPSKSKQ
KKIPYKNIPSVTLGRLAIDRSLQGQGWGATLVAHAMKVVWSASLAVGIHGLFVEALNKKAHTFYQSLGFIPLVGENENAL
FFPTKSIELLFTQSD

Download         Length: 528 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9910.31 Da        Isoelectric Point: 10.0863

>AT273796 WP_001277108.1 NZ_CP119120:c4457311-4457045 [Escherichia coli]
MSAVKKQRIDLRLTDDDKSMIEEAAAISNQSVSQFMLNSASQRAAEVIEQHRRVILNEESWTRVMDALSNPPSPGEKLKR
AAKRLQGM

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829CLZ4

Antitoxin

Source ID Structure
PDB 6GTS
PDB 6AJN
PDB 6GTQ
PDB 6GTO
PDB 6GTR
PDB 6AJM
AlphaFold DB A0A829CN24

References