Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3889448..3890102 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag PYZ88_RS18890 Protein ID WP_000244777.1
Coordinates 3889448..3889855 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PYZ88_RS18895 Protein ID WP_000354046.1
Coordinates 3889836..3890102 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS18870 (3885405) 3885405..3887138 - 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -
PYZ88_RS18875 (3887144) 3887144..3887854 - 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PYZ88_RS18880 (3887879) 3887879..3888775 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PYZ88_RS18885 (3888887) 3888887..3889408 + 522 WP_001055874.1 flavodoxin FldB -
PYZ88_RS18890 (3889448) 3889448..3889855 - 408 WP_000244777.1 protein YgfX Toxin
PYZ88_RS18895 (3889836) 3889836..3890102 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PYZ88_RS18900 (3890345) 3890345..3891325 + 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PYZ88_RS18905 (3891402) 3891402..3892061 - 660 WP_000250274.1 hemolysin III family protein -
PYZ88_RS18910 (3892225) 3892225..3892536 - 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
PYZ88_RS18915 (3892581) 3892581..3894014 + 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PYZ88_RS18920 (3894071) 3894071..3894814 - 744 Protein_3679 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T273793 WP_000244777.1 NZ_CP119120:c3889855-3889448 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT273793 WP_000354046.1 NZ_CP119120:c3890102-3889836 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References