Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3448208..3448833 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYZ88_RS16780 Protein ID WP_000911330.1
Coordinates 3448208..3448606 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag PYZ88_RS16785 Protein ID WP_000450524.1
Coordinates 3448606..3448833 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS16760 (3444086) 3444086..3444286 + 201 WP_000383836.1 YpfN family protein -
PYZ88_RS16765 (3444396) 3444396..3445094 - 699 WP_000679823.1 esterase -
PYZ88_RS16770 (3445168) 3445168..3447183 - 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
PYZ88_RS16775 (3447198) 3447198..3448061 - 864 WP_001267507.1 neutral zinc metallopeptidase -
PYZ88_RS16780 (3448208) 3448208..3448606 - 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
PYZ88_RS16785 (3448606) 3448606..3448833 - 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
PYZ88_RS16790 (3448987) 3448987..3449700 - 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
PYZ88_RS16795 (3449913) 3449913..3450947 - 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
PYZ88_RS16800 (3450964) 3450964..3451842 - 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
PYZ88_RS16805 (3451988) 3451988..3452560 + 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
PYZ88_RS16810 (3452560) 3452560..3453030 + 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T273790 WP_000911330.1 NZ_CP119120:c3448606-3448208 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT273790 WP_000450524.1 NZ_CP119120:c3448833-3448606 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References