Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1238694..1239312 Replicon chromosome
Accession NZ_CP119120
Organism Escherichia coli strain GENOMIC22-004

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PYZ88_RS06015 Protein ID WP_001291435.1
Coordinates 1238694..1238912 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PYZ88_RS06020 Protein ID WP_000344800.1
Coordinates 1238938..1239312 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYZ88_RS05980 (1233983) 1233983..1234555 + 573 WP_000779831.1 YbaY family lipoprotein -
PYZ88_RS05985 (1234586) 1234586..1234897 - 312 WP_000409911.1 MGMT family protein -
PYZ88_RS05995 (1235276) 1235276..1235629 + 354 WP_000878140.1 DUF1428 domain-containing protein -
PYZ88_RS06000 (1235671) 1235671..1237221 - 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PYZ88_RS06005 (1237385) 1237385..1237855 - 471 WP_000136192.1 YlaC family protein -
PYZ88_RS06010 (1237971) 1237971..1238522 - 552 WP_000102568.1 maltose O-acetyltransferase -
PYZ88_RS06015 (1238694) 1238694..1238912 - 219 WP_001291435.1 HHA domain-containing protein Toxin
PYZ88_RS06020 (1238938) 1238938..1239312 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PYZ88_RS06025 (1239858) 1239858..1243007 - 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PYZ88_RS06030 (1243030) 1243030..1244223 - 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T273782 WP_001291435.1 NZ_CP119120:c1238912-1238694 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT273782 WP_000344800.1 NZ_CP119120:c1239312-1238938 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References