Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2244646..2245160 Replicon chromosome
Accession NZ_CP119113
Organism Staphylococcus aureus strain GENOMIC22-002

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PXV46_RS11220 Protein ID WP_000581792.1
Coordinates 2244646..2244855 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PXV46_RS11225 Protein ID WP_000138932.1
Coordinates 2244867..2245160 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV46_RS11200 (PXV46_11200) 2240157..2241512 - 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
PXV46_RS11205 (PXV46_11205) 2241527..2242597 - 1071 WP_000159641.1 D-alanine--D-alanine ligase -
PXV46_RS11210 (PXV46_11210) 2242915..2244117 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PXV46_RS11215 (PXV46_11215) 2244381..2244518 - 138 WP_000828354.1 Lmo0850 family protein -
PXV46_RS11220 (PXV46_11220) 2244646..2244855 - 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PXV46_RS11225 (PXV46_11225) 2244867..2245160 - 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PXV46_RS11230 (PXV46_11230) 2245326..2246810 + 1485 WP_000571550.1 cardiolipin synthase -
PXV46_RS11235 (PXV46_11235) 2246838..2247485 + 648 WP_001187614.1 HD domain-containing protein -
PXV46_RS11240 (PXV46_11240) 2248042..2248104 + 63 Protein_2174 hypothetical protein -
PXV46_RS11245 (PXV46_11245) 2248082..2249397 - 1316 Protein_2175 ISL3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T273777 WP_000581792.1 NZ_CP119113:c2244855-2244646 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT273777 WP_000138932.1 NZ_CP119113:c2245160-2244867 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References