Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2224909..2225438 Replicon chromosome
Accession NZ_CP119113
Organism Staphylococcus aureus strain GENOMIC22-002

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PXV46_RS11130 Protein ID WP_000621175.1
Coordinates 2224909..2225271 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PXV46_RS11135 Protein ID WP_000948331.1
Coordinates 2225268..2225438 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV46_RS11110 (PXV46_11110) 2221887..2222657 - 771 WP_001041107.1 RNA polymerase sigma factor SigB -
PXV46_RS11115 (PXV46_11115) 2222632..2223111 - 480 WP_001190825.1 anti-sigma B factor RsbW -
PXV46_RS11120 (PXV46_11120) 2223113..2223439 - 327 WP_001052491.1 anti-sigma factor antagonist -
PXV46_RS11125 (PXV46_11125) 2223558..2224559 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PXV46_RS11130 (PXV46_11130) 2224909..2225271 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PXV46_RS11135 (PXV46_11135) 2225268..2225438 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PXV46_RS11140 (PXV46_11140) 2225523..2226671 - 1149 WP_001281139.1 alanine racemase -
PXV46_RS11145 (PXV46_11145) 2226737..2227096 - 360 WP_000581197.1 holo-ACP synthase -
PXV46_RS11150 (PXV46_11150) 2227100..2227591 - 492 WP_001286980.1 PH domain-containing protein -
PXV46_RS11155 (PXV46_11155) 2227584..2229161 - 1578 WP_001294650.1 PH domain-containing protein -
PXV46_RS11160 (PXV46_11160) 2229154..2229633 - 480 WP_001287081.1 hypothetical protein -
PXV46_RS11165 (PXV46_11165) 2229842..2230402 - 561 WP_001092419.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273776 WP_000621175.1 NZ_CP119113:c2225271-2224909 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273776 WP_000948331.1 NZ_CP119113:c2225438-2225268 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References