Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2015370..2016146 Replicon chromosome
Accession NZ_CP119113
Organism Staphylococcus aureus strain GENOMIC22-002

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PXV46_RS09925 Protein ID WP_000031108.1
Coordinates 2015370..2015522 (-) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID W8U4V4
Locus tag PXV46_RS09930 Protein ID WP_001251224.1
Coordinates 2015547..2016146 (-) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV46_RS09910 (PXV46_09910) 2011575..2012396 + 822 WP_000669380.1 RluA family pseudouridine synthase -
PXV46_RS09915 (PXV46_09915) 2012851..2014236 - 1386 WP_000116238.1 class II fumarate hydratase -
PXV46_RS09920 (PXV46_09920) 2014432..2014827 - 396 WP_000901018.1 hypothetical protein -
PXV46_RS09925 (PXV46_09925) 2015370..2015522 - 153 WP_000031108.1 SAS053 family protein Toxin
PXV46_RS09930 (PXV46_09930) 2015547..2016146 - 600 WP_001251224.1 glucosamine-6-phosphate isomerase Antitoxin
PXV46_RS09935 (PXV46_09935) 2016305..2016775 - 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PXV46_RS09940 (PXV46_09940) 2016780..2017907 - 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PXV46_RS09945 (PXV46_09945) 2018058..2018780 - 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
PXV46_RS09950 (PXV46_09950) 2018773..2020230 - 1458 WP_000649908.1 ABC transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T273774 WP_000031108.1 NZ_CP119113:c2015522-2015370 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22343.47 Da        Isoelectric Point: 5.1445

>AT273774 WP_001251224.1 NZ_CP119113:c2016146-2015547 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure
AlphaFold DB W8U4V4

References