273768

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 2618414..2619202 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name - Uniprot ID A0A2I7Y5B3
Locus tag PXV45_RS13285 Protein ID WP_000525004.1
Coordinates 2618741..2619202 (+) Length 154 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag PXV45_RS13280 Protein ID WP_000333630.1
Coordinates 2618414..2618728 (+) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS13220 (2613556) 2613556..2614722 - 1167 WP_031794996.1 DUF2800 domain-containing protein -
PXV45_RS13225 (2614719) 2614719..2615081 - 363 WP_000985976.1 hypothetical protein -
PXV45_RS13230 (2615096) 2615096..2615419 - 324 WP_000174994.1 hypothetical protein -
PXV45_RS13235 (2615498) 2615498..2615659 - 162 WP_001285948.1 DUF1270 domain-containing protein -
PXV45_RS13240 (2615672) 2615672..2615935 - 264 WP_016187436.1 helix-turn-helix domain-containing protein -
PXV45_RS13245 (2615960) 2615960..2616175 - 216 WP_001097552.1 hypothetical protein -
PXV45_RS13250 (2616230) 2616230..2616595 + 366 WP_016170627.1 hypothetical protein -
PXV45_RS13255 (2616564) 2616564..2616809 - 246 WP_001025401.1 DUF2829 domain-containing protein -
PXV45_RS13260 (2616865) 2616865..2617074 + 210 WP_000642492.1 hypothetical protein -
PXV45_RS13265 (2617064) 2617064..2617207 - 144 WP_000939498.1 hypothetical protein -
PXV45_RS13270 (2617236) 2617236..2618012 - 777 WP_001148544.1 Rha family transcriptional regulator -
PXV45_RS13275 (2618026) 2618026..2618262 - 237 WP_001121027.1 helix-turn-helix transcriptional regulator -
PXV45_RS13280 (2618414) 2618414..2618728 + 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
PXV45_RS13285 (2618741) 2618741..2619202 + 462 WP_000525004.1 hypothetical protein Toxin
PXV45_RS13290 (2619220) 2619220..2619804 + 585 WP_031918390.1 hypothetical protein -
PXV45_RS13295 (2620035) 2620035..2620181 + 147 WP_074370993.1 hypothetical protein -
PXV45_RS13300 (2620178) 2620178..2620792 - 615 WP_000191466.1 hypothetical protein -
PXV45_RS13305 (2620918) 2620918..2622123 + 1206 WP_031795352.1 tyrosine-type recombinase/integrase -
PXV45_RS13310 (2622217) 2622217..2624151 - 1935 Protein_2580 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - geh 2576909..2631367 54458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 154 a.a.        Molecular weight: 18074.46 Da        Isoelectric Point: 4.6915

>T273768 WP_000525004.1 NZ_CP119109:2618741-2619202 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI

Download         Length: 462 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT273768 WP_000333630.1 NZ_CP119109:2618414-2618728 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I7Y5B3

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References