Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Xre-MNT/HTH_26(antitoxin)
Location 1194031..1195139 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name MNTss Uniprot ID A0A0M4MHJ8
Locus tag PXV45_RS06140 Protein ID WP_002303392.1
Coordinates 1194270..1195139 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name Xress Uniprot ID B9DSK1
Locus tag PXV45_RS06135 Protein ID WP_002303393.1
Coordinates 1194031..1194255 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS06115 (1189161) 1189161..1189595 + 435 WP_002325146.1 hypothetical protein -
PXV45_RS06120 (1190038) 1190038..1191522 + 1485 WP_074371031.1 ABC-F type ribosomal protection protein Lsa(E) -
PXV45_RS06125 (1191576) 1191576..1192379 + 804 WP_002294514.1 lincosamide nucleotidyltransferase Lnu(B) -
PXV45_RS06130 (1193067) 1193067..1193888 + 822 Protein_1171 recombinase zinc beta ribbon domain-containing protein -
PXV45_RS06135 (1194031) 1194031..1194255 + 225 WP_002303393.1 helix-turn-helix transcriptional regulator Antitoxin
PXV45_RS06140 (1194270) 1194270..1195139 + 870 WP_002303392.1 nucleotidyltransferase domain-containing protein Toxin
PXV45_RS06145 (1195120) 1195120..1195806 + 687 WP_224103254.1 class I SAM-dependent methyltransferase -
PXV45_RS06150 (1196041) 1196041..1196187 + 147 Protein_1175 JAB domain-containing protein -
PXV45_RS06155 (1196255) 1196255..1196539 + 285 WP_000171859.1 hypothetical protein -
PXV45_RS06160 (1196656) 1196656..1196853 - 198 WP_000025835.1 hypothetical protein -
PXV45_RS06165 (1197013) 1197013..1197486 + 474 WP_001236734.1 DUF4930 family protein -
PXV45_RS06170 (1197560) 1197560..1197679 + 120 WP_000840603.1 hypothetical protein -
PXV45_RS06175 (1197877) 1197877..1198719 + 843 WP_000911033.1 rod shape-determining protein MreC -
PXV45_RS06180 (1198719) 1198719..1199249 + 531 WP_001259929.1 rod shape-determining protein MreD -
PXV45_RS06185 (1199736) 1199736..1200044 + 309 WP_000457386.1 50S ribosomal protein L21 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island lsa(E) / lnu(B) - 1189161..1197486 8325


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polymerase, nucleotidyl transferase domain

(12-111)

Antitoxin

Cro/C1-type helix-turn-helix domain

(4-57)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 32807.38 Da        Isoelectric Point: 4.7269

>T273764 WP_002303392.1 NZ_CP119109:1194270-1195139 [Staphylococcus aureus]
MVGNVIQIVTEKLSSLPFIEGIVLGGSRARSTHTENSDIDIGIYYNSDSFDLTAINQIATELDDENRNNLVVPPGAWGDW
VNGGGWLVINGCHVDLILRDIKRVEQIIKDTEQGIVTANYQTGHPHGYISAMYRGELAISKILYAKNESLCELKKQAEIY
PTALKKSLMNFFIFEAEFSLMFVKANAGAEDKYYIAGHVFRIISCLNQVLFACNNAYCINEKKAIKLLETFEYKPEKYAE
RVNHIFEVLGLSLFECYDMTEKLYKEVNEIVSEINNFLNEESSDERKQI

Download         Length: 870 bp

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8351.65 Da        Isoelectric Point: 4.5357

>AT273764 WP_002303393.1 NZ_CP119109:1194031-1194255 [Staphylococcus aureus]
MTTAEMIKELCEQMNISVSELARRIGQTPQNFNKKLQRETVTLDELKAIADVLGVKFVQAFILPDGDEIKISNE

Download         Length: 225 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M4MHJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A1M5SHM7

References