273763

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 981234..982010 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name tsbT Uniprot ID X5E2E6
Locus tag PXV45_RS05120 Protein ID WP_000031108.1
Coordinates 981858..982010 (+) Length 51 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag PXV45_RS05115 Protein ID WP_074371037.1
Coordinates 981234..981833 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS05095 (977150) 977150..978607 + 1458 WP_000649908.1 ABC transporter permease subunit -
PXV45_RS05100 (978600) 978600..979322 + 723 WP_031774878.1 amino acid ABC transporter ATP-binding protein -
PXV45_RS05105 (979473) 979473..980600 + 1128 WP_000379980.1 tRNA epoxyqueuosine(34) reductase QueG -
PXV45_RS05110 (980605) 980605..981075 + 471 WP_000181394.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
PXV45_RS05115 (981234) 981234..981833 + 600 WP_074371037.1 glucosamine-6-phosphate isomerase Antitoxin
PXV45_RS05120 (981858) 981858..982010 + 153 WP_000031108.1 SAS053 family protein Toxin
PXV45_RS05125 (982553) 982553..982948 + 396 WP_000901018.1 hypothetical protein -
PXV45_RS05130 (983144) 983144..984529 + 1386 WP_000116238.1 class II fumarate hydratase -
PXV45_RS05135 (984984) 984984..985805 - 822 WP_000669380.1 RluA family pseudouridine synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(124-196)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5936.28 Da        Isoelectric Point: 3.8962

>T273763 WP_000031108.1 NZ_CP119109:981858-982010 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVTDFEDLKELGKEMEQISDQNDQEKNSEEDSQ

Download         Length: 153 bp

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22355.53 Da        Isoelectric Point: 5.1445

>AT273763 WP_074371037.1 NZ_CP119109:981234-981833 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNVEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLILQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Download         Length: 600 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB X5E2E6

Antitoxin

Source ID Structure

References