Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 786708..787237 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PXV45_RS03915 Protein ID WP_000621175.1
Coordinates 786875..787237 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag PXV45_RS03910 Protein ID WP_000948331.1
Coordinates 786708..786878 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS03880 (781744) 781744..782304 + 561 WP_001092419.1 K(+)-transporting ATPase subunit C -
PXV45_RS03885 (782513) 782513..782992 + 480 WP_001287081.1 hypothetical protein -
PXV45_RS03890 (782985) 782985..784562 + 1578 WP_001294650.1 PH domain-containing protein -
PXV45_RS03895 (784555) 784555..785046 + 492 WP_001286980.1 PH domain-containing protein -
PXV45_RS03900 (785050) 785050..785409 + 360 WP_000581197.1 holo-ACP synthase -
PXV45_RS03905 (785475) 785475..786623 + 1149 WP_001281139.1 alanine racemase -
PXV45_RS03910 (786708) 786708..786878 + 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
PXV45_RS03915 (786875) 786875..787237 + 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PXV45_RS03920 (787587) 787587..788588 + 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
PXV45_RS03925 (788707) 788707..789033 + 327 WP_001052491.1 anti-sigma factor antagonist -
PXV45_RS03930 (789035) 789035..789514 + 480 WP_001190825.1 anti-sigma B factor RsbW -
PXV45_RS03935 (789489) 789489..790259 + 771 WP_001041107.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T273759 WP_000621175.1 NZ_CP119109:786875-787237 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT273759 WP_000948331.1 NZ_CP119109:786708-786878 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References