273758

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 766986..767500 Replicon chromosome
Accession NZ_CP119109
Organism Staphylococcus aureus strain GENOMIC22-001

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag PXV45_RS03825 Protein ID WP_000581792.1
Coordinates 767291..767500 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag PXV45_RS03820 Protein ID WP_000138932.1
Coordinates 766986..767279 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXV45_RS03800 (762749) 762749..764064 + 1316 Protein_748 ISL3 family transposase -
PXV45_RS03805 (764042) 764042..764104 - 63 Protein_749 hypothetical protein -
PXV45_RS03810 (764661) 764661..765308 - 648 WP_001187614.1 HD domain-containing protein -
PXV45_RS03815 (765336) 765336..766820 - 1485 WP_000571550.1 cardiolipin synthase -
PXV45_RS03820 (766986) 766986..767279 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
PXV45_RS03825 (767291) 767291..767500 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
PXV45_RS03830 (767628) 767628..767765 + 138 WP_000828354.1 Lmo0850 family protein -
PXV45_RS03835 (768029) 768029..769231 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
PXV45_RS03840 (769549) 769549..770619 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
PXV45_RS03845 (770634) 770634..771989 + 1356 WP_000611457.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T273758 WP_000581792.1 NZ_CP119109:767291-767500 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT273758 WP_000138932.1 NZ_CP119109:766986-767279 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References