Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/RHH-MazF
Location 3482077..3482669 Replicon chromosome
Accession NZ_CP119108
Organism Microbacterium sp. KACC 23027

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag PU630_RS16525 Protein ID WP_275278150.1
Coordinates 3482077..3482445 (-) Length 123 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PU630_RS16530 Protein ID WP_275278151.1
Coordinates 3482442..3482669 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU630_RS16505 (PU630_16505) 3478920..3479801 - 882 WP_275278146.1 NAD(P)H-binding protein -
PU630_RS16510 (PU630_16510) 3479893..3480450 + 558 WP_275278147.1 TetR/AcrR family transcriptional regulator -
PU630_RS16515 (PU630_16515) 3480508..3481671 + 1164 WP_275278148.1 acyl-CoA dehydrogenase family protein -
PU630_RS16520 (PU630_16520) 3481741..3482037 + 297 WP_275278149.1 DUF503 family protein -
PU630_RS16525 (PU630_16525) 3482077..3482445 - 369 WP_275278150.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PU630_RS16530 (PU630_16530) 3482442..3482669 - 228 WP_275278151.1 ribbon-helix-helix domain-containing protein Antitoxin
PU630_RS16535 (PU630_16535) 3482713..3483369 - 657 WP_275278152.1 GntR family transcriptional regulator -
PU630_RS16540 (PU630_16540) 3483470..3484762 + 1293 WP_275278153.1 MFS transporter -
PU630_RS16545 (PU630_16545) 3485007..3486281 + 1275 WP_275278154.1 M18 family aminopeptidase -
PU630_RS16550 (PU630_16550) 3486372..3486863 + 492 WP_275278155.1 bifunctional nuclease family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-119)

Antitoxin

Antitoxin ParD

(4-67)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 12792.82 Da        Isoelectric Point: 10.9753

>T273752 WP_275278150.1 NZ_CP119108:c3482445-3482077 [Microbacterium sp. KACC 23027]
VSGELPFVRRGAIVLVDLDPSDGSEAAKLRPAVVVSNNTANAAALRTGRGVLTVVPVTSNTEKVYPFQVLLPAASTGLSR
DSKAQAEQLRAVSLLRVRRVVGWVPGDLMAGLDAAVRLHLAL

Download         Length: 369 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 7912.51 Da        Isoelectric Point: 3.7056

>AT273752 WP_275278151.1 NZ_CP119108:c3482669-3482442 [Microbacterium sp. KACC 23027]
MVSKVSISLDDDDVAYLDGQSLSGRFASRSAAVQAAIRLLRESELSDAYAEAYGSWDESDDAAPWDATAADGLPA

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References