Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4510411..4511042 Replicon chromosome
Accession NZ_CP119107
Organism Pullulanibacillus sp. KACC 23026

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag PU629_RS20965 Protein ID WP_275281956.1
Coordinates 4510411..4510761 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag PU629_RS20970 Protein ID WP_275281957.1
Coordinates 4510767..4511042 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PU629_RS20930 (PU629_20930) 4505959..4506756 - 798 WP_275281949.1 RNA polymerase sigma factor SigB -
PU629_RS20935 (PU629_20935) 4506725..4507207 - 483 WP_275281950.1 anti-sigma B factor RsbW -
PU629_RS20940 (PU629_20940) 4507204..4507530 - 327 WP_275281951.1 STAS domain-containing protein -
PU629_RS20945 (PU629_20945) 4507588..4508595 - 1008 WP_275281952.1 PP2C family protein-serine/threonine phosphatase -
PU629_RS20950 (PU629_20950) 4508616..4509017 - 402 WP_275281953.1 anti-sigma regulatory factor -
PU629_RS20955 (PU629_20955) 4509017..4509376 - 360 WP_275281954.1 STAS domain-containing protein -
PU629_RS20960 (PU629_20960) 4509379..4510209 - 831 WP_275281955.1 STAS domain-containing protein -
PU629_RS20965 (PU629_20965) 4510411..4510761 - 351 WP_275281956.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
PU629_RS20970 (PU629_20970) 4510767..4511042 - 276 WP_275281957.1 antitoxin endoai Antitoxin
PU629_RS20975 (PU629_20975) 4511159..4512307 - 1149 WP_275281959.1 alanine racemase -
PU629_RS20980 (PU629_20980) 4512453..4513454 - 1002 WP_275281960.1 outer membrane lipoprotein carrier protein LolA -
PU629_RS20985 (PU629_20985) 4513736..4514101 - 366 WP_275281961.1 holo-ACP synthase -
PU629_RS20990 (PU629_20990) 4514254..4514868 + 615 WP_275281962.1 rhomboid family intramembrane serine protease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-111)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12956.99 Da        Isoelectric Point: 5.7168

>T273746 WP_275281956.1 NZ_CP119107:c4510761-4510411 [Pullulanibacillus sp. KACC 23026]
VIVKRGDVYFADLSPVVGSEQGGVRPVLIIQNDIGNRFSPTVVVAAITAQIQKAKLPTHIEIDAKRYGFDRDSVILLEQI
RTIDKQRLTDKITHLDEEMMARVNEAIQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10482.88 Da        Isoelectric Point: 4.7133

>AT273746 WP_275281957.1 NZ_CP119107:c4511042-4510767 [Pullulanibacillus sp. KACC 23026]
MAESSEEIKVRLPQHLLQEIDGMARLDNLNRNDFLSQAVSSYLKERNKRQIREAMRQGYMEMAKINLNLASEAFIAEEEA
ENTLERLVSGV

Download         Length: 276 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References