Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 198123..199548 Replicon chromosome
Accession NZ_CP119078
Organism Legionella cardiaca strain H63

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag PXX05_RS00895 Protein ID WP_275089176.1
Coordinates 198123..199334 (-) Length 404 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag PXX05_RS00900 Protein ID WP_275089177.1
Coordinates 199321..199548 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PXX05_RS00870 (PXX05_00870) 193468..193908 + 441 WP_275089171.1 ATP synthase subunit C -
PXX05_RS00875 (PXX05_00875) 193918..194622 + 705 WP_275089172.1 hypothetical protein -
PXX05_RS00880 (PXX05_00880) 194619..195281 + 663 WP_275089173.1 DUF2764 family protein -
PXX05_RS00885 (PXX05_00885) 195321..197147 + 1827 WP_275089174.1 V-type ATP synthase subunit A -
PXX05_RS00890 (PXX05_00890) 197214..197954 - 741 WP_275089175.1 hypothetical protein -
PXX05_RS00895 (PXX05_00895) 198123..199334 - 1212 WP_275089176.1 type II toxin-antitoxin system HipA family toxin Toxin
PXX05_RS00900 (PXX05_00900) 199321..199548 - 228 WP_275089177.1 type II toxin-antitoxin system Y4mF family antitoxin Antitoxin
PXX05_RS00905 (PXX05_00905) 199786..200601 + 816 WP_275089178.1 hypothetical protein -
PXX05_RS00910 (PXX05_00910) 200621..202132 - 1512 WP_275089179.1 serine hydrolase -
PXX05_RS00915 (PXX05_00915) 202281..203471 + 1191 WP_275089180.1 MFS transporter -
PXX05_RS00920 (PXX05_00920) 203670..204233 + 564 WP_275089181.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(147-380)

Antitoxin

Cro/C1-type helix-turn-helix domain

(9-66)


Sequences

Toxin        


Download         Length: 404 a.a.        Molecular weight: 45132.81 Da        Isoelectric Point: 6.4121

>T273741 WP_275089176.1 NZ_CP119078:c199334-198123 [Legionella cardiaca]
MQNHKLDVYLNQTLIGQLNIDVFGDMVFVYDGNYLENKNNRPLSRSLPLQQEPYTAKQCRPFFSGLLPEAHLRTSIARQL
GISEKNDFALLTAIGGECAGAITLLPESARQSDLKPDYRIIGDNAVADILQTLQQRPMLAGEDGIRLSLAGAQDKLAIAI
IDDHIAIPLNGAPSTHILKPVNRDFPSLIENECFCLELARKIGLNAVEATLHHTNGIPYLLVKRYDRIATESGIQRIHQE
DFCQAMGISPEMKYQREGGPGVSDCFQLLRTASSLAVIDIKELLQGILFNLFIGNNDAHGKNFSFLYQGQQTRLAPFYDM
ISTIYYPNLATKMAMKIGSKYEFDGLFPRHIVQMAEEANLSGALVQKEAMKILDKIQNNITESPFTTTILQRIDKFNQRF
QQV

Download         Length: 1212 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8301.83 Da        Isoelectric Point: 10.4869

>AT273741 WP_275089177.1 NZ_CP119078:c199548-199321 [Legionella cardiaca]
MIQSAENIGQVIRKVRKDLGITQRDLALSSGTGLRFIIELEKGKSTCQIGKVLQVLQVLGIQLRLFHAEIEIAKS

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References