Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4778512..4779128 Replicon chromosome
Accession NZ_CP119076
Organism Klebsiella aerogenes strain RX7.1

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PYR66_RS22650 Protein ID WP_275048091.1
Coordinates 4778512..4778886 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PYR66_RS22655 Protein ID WP_275050401.1
Coordinates 4778886..4779128 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR66_RS22635 (PYR66_22635) 4776013..4776915 + 903 WP_275048088.1 formate dehydrogenase subunit beta -
PYR66_RS22640 (PYR66_22640) 4776912..4777538 + 627 WP_275048089.1 formate dehydrogenase cytochrome b556 subunit -
PYR66_RS22645 (PYR66_22645) 4777544..4778473 + 930 WP_275048090.1 formate dehydrogenase accessory protein FdhE -
PYR66_RS22650 (PYR66_22650) 4778512..4778886 - 375 WP_275048091.1 type II toxin-antitoxin system VapC family toxin Toxin
PYR66_RS22655 (PYR66_22655) 4778886..4779128 - 243 WP_275050401.1 CopG family transcriptional regulator Antitoxin
PYR66_RS22660 (PYR66_22660) 4779332..4780249 + 918 WP_275048092.1 alpha/beta hydrolase -
PYR66_RS22665 (PYR66_22665) 4780266..4781207 - 942 WP_275048093.1 fatty acid biosynthesis protein FabY -
PYR66_RS22670 (PYR66_22670) 4781252..4781689 - 438 WP_275048094.1 D-aminoacyl-tRNA deacylase -
PYR66_RS22675 (PYR66_22675) 4781686..4782546 - 861 WP_275048095.1 virulence factor BrkB family protein -
PYR66_RS22680 (PYR66_22680) 4782540..4783139 - 600 WP_275048096.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14247.52 Da        Isoelectric Point: 6.2293

>T273740 WP_275048091.1 NZ_CP119076:c4778886-4778512 [Klebsiella aerogenes]
MVKGVALFDTNILIDLFSGRREAQQALEAWPLQNAISLITWMEVMVGAKKYHQEQRTRIALRSFNIIDVSHDIAERSVDL
RQEYRMTLPDAIILATAQIHRLELITRNTKDFADLPGVVIPYEL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9448.73 Da        Isoelectric Point: 4.4821

>AT273740 WP_275050401.1 NZ_CP119076:c4779128-4778886 [Klebsiella aerogenes]
MMVERDMGRILLDLSDDVIKRLDDLKAQRNLPRAELLREAVEQYLEKQDRAKESISGALGLWQGCEEDGVEYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References