273739

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yfjZ-ypjF/CbtA-CbeA
Location 4343319..4343977 Replicon chromosome
Accession NZ_CP119076
Organism Klebsiella aerogenes strain RX7.1

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag PYR66_RS20665 Protein ID WP_275047772.1
Coordinates 4343319..4343636 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID G9Z400
Locus tag PYR66_RS20670 Protein ID WP_006818666.1
Coordinates 4343657..4343977 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PYR66_RS20650 (PYR66_20650) 4339364..4340248 + 885 WP_275047770.1 DNA adenine methylase -
PYR66_RS20655 (PYR66_20655) 4340753..4342017 - 1265 Protein_4045 integrase arm-type DNA-binding domain-containing protein -
PYR66_RS20660 (PYR66_20660) 4342536..4343180 + 645 WP_275047771.1 hypothetical protein -
PYR66_RS20665 (PYR66_20665) 4343319..4343636 - 318 WP_275047772.1 TA system toxin CbtA family protein Toxin
PYR66_RS20670 (PYR66_20670) 4343657..4343977 - 321 WP_006818666.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
PYR66_RS20675 (PYR66_20675) 4343996..4344217 - 222 WP_160955864.1 DUF987 domain-containing protein -
PYR66_RS20680 (PYR66_20680) 4344226..4344708 - 483 WP_275047773.1 DNA repair protein RadC -
PYR66_RS20685 (PYR66_20685) 4344717..4345175 - 459 WP_275047774.1 antirestriction protein -
PYR66_RS20690 (PYR66_20690) 4345261..4345497 - 237 WP_008815079.1 DUF905 domain-containing protein -
PYR66_RS20695 (PYR66_20695) 4345575..4345985 - 411 WP_275047775.1 hypothetical protein -
PYR66_RS20700 (PYR66_20700) 4346052..4346489 - 438 WP_275047776.1 hypothetical protein -
PYR66_RS20705 (PYR66_20705) 4346531..4347067 - 537 WP_061068399.1 DUF4339 domain-containing protein -
PYR66_RS20710 (PYR66_20710) 4347093..4347803 - 711 WP_006818658.1 DeoR family transcriptional regulator -
PYR66_RS20715 (PYR66_20715) 4348012..4348836 - 825 WP_275047777.1 DUF932 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4337416..4370830 33414


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-105)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 11952.73 Da        Isoelectric Point: 5.6772

>T273739 WP_275047772.1 NZ_CP119076:c4343636-4343319 [Klebsiella aerogenes]
MKNLPATISRAAEPCLSPVAVWQMLLTRLLEQHYGLALNDTPFSDETVIQEHIDAGITLSDAINFLVDKYELVRIDRRGF
SWQEQSPYLRAVDILRARQATGLLR

Download         Length: 318 bp

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12049.68 Da        Isoelectric Point: 7.0264

>AT273739 WP_006818666.1 NZ_CP119076:c4343977-4343657 [Klebsiella aerogenes]
MRSHVTWGLQRDITPRLGARLVQEGNRLHYLTDRASITGQFSDAECLKLDVAFPHFISQMESMLTTSEMNPRHAHCVTLY
HNGFTCEADTLGSCGYVYIAIYPTQR

Download         Length: 321 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB G9Z400

References